Clinical Research on the Relation Between Body Mass Index, Motilin and Slow Transit Constipation

Overview

Journal Gastroenterology Res

Specialty Gastroenterology

Date 2016 Dec 14

PMID 27956980

Citations 11

Authors

Hong Bin Chen

Yue Huang

Hui Wen Song

Xiao Lin Li

Song He

Jia Tia Xie

Chun Huang

Sheng Jun Zhang

Jia Liu

Ying Zou

Affiliations

Soon will be listed here.

Abstract

Background: Constipation is a common clinical symptom but its etiology remains unknown. The aims of the study are to discuss the relation between body mass index (BMI), motilin and the slow transit constipation (STC).

Methods: A total of 178 patients with STC and 123 healthy volunteers as controls were divided into three groups according to the BMI, group A (BMI <20), group B (BMI 20-25), and group C (BMI > 25). Fasting and one hour postprandial plasma motilin were measured and the results were analyzed.

Results: There was significant difference in the constituent ratio between STC patients and healthy controls (p < 0.05). The percentage of group A, B and C in STC patients was 49.4% (88/178), 23.0% (41/178) and 27.6% (49/178), respectively; and group A had a higher percentage. Plasma motilin of fasting and one hour postprandial in STC patients of group A was significantly lower than that of group B and C (p < 0.05), but there was no difference between group B and C (p > 0.05). There was no significant difference in the results of plasma motilin of fasting and one hour postprandial among the three groups of healthy controls (p > 0.05). Plasma motilin of fasting and one hour postprandial in STC patients of group A was significantly lower than those healthy controls of group A (p < 0.05). The same results of plasma motilin of fasting and one hour postprandial could be seen in group B and C, respectively (p < 0.05).

Conclusions: A higher proportion of low BMI sufferers was found in the STC patients. The reason may be related to the lower release of the plasma motilin.

Citing Articles

Aberrant bowel movement frequencies coincide with increased microbe-derived blood metabolites associated with reduced organ function.

Johnson-Martinez J, Diener C, Levine A, Wilmanski T, Suskind D, Ralevski A Cell Rep Med. 2024; 5(7):101646.

PMID: 39019013 PMC: 11293344. DOI: 10.1016/j.xcrm.2024.101646.

Generally-healthy individuals with aberrant bowel movement frequencies show enrichment for microbially-derived blood metabolites associated with reduced kidney function.

Johnson-Martinez J, Diener C, Levine A, Wilmanski T, Suskind D, Ralevski A bioRxiv. 2023; .

PMID: 36945445 PMC: 10028848. DOI: 10.1101/2023.03.04.531100.

CircORC2 is involved in the pathogenesis of slow transit constipation via modulating the signalling of miR-19a and neurotensin/motilin.

Wang Y, Lu R, Shi J, Zhao S, Jiang X, Gu X J Cell Mol Med. 2021; 25(8):3754-3764.

PMID: 33629528 PMC: 8051712. DOI: 10.1111/jcmm.16211.

Oleanolic acid ameliorates intestinal alterations associated with EAE.

Gutierrez B, Gallardo I, Ruiz L, Alvarez Y, Cachofeiro V, Margolles A J Neuroinflammation. 2020; 17(1):363.

PMID: 33246492 PMC: 7697371. DOI: 10.1186/s12974-020-02042-6.

Curative Effect and Mechanism of Guiren Runchang Granules on Morphine-Induced Slow Transit Constipation in Mice.

Sun Y, Yan C, Jin S, Shi C, Zhao J, Li G Evid Based Complement Alternat Med. 2020; 2020:5493192.

PMID: 33029167 PMC: 7530485. DOI: 10.1155/2020/5493192.

References

Allen J, Christofides N, Cramer P, STEINERT J, Bloom S . Elevated motilin levels in patients treated with antidepressant and neuroleptic drugs. Br J Psychiatry. 1982; 141:27-9. DOI: 10.1192/bjp.141.1.27. View

Emmanuel A, Mason H, Kamm M . Relationship between psychological state and level of activity of extrinsic gut innervation in patients with a functional gut disorder. Gut. 2001; 49(2):209-13. PMC: 1728413. DOI: 10.1136/gut.49.2.209. View

Dykes S, Bass C . Chronic idiopathic constipation: a psychological enquiry. Eur J Gastroenterol Hepatol. 2001; 13(1):39-44. DOI: 10.1097/00042737-200101000-00007. View

van der Veek P, Biemond I, Masclee A . Proximal and distal gut hormone secretion in irritable bowel syndrome. Scand J Gastroenterol. 2006; 41(2):170-7. DOI: 10.1080/00365520500206210. View

Dryburgh J, Brown J . Radioimmunoassay for motilin. Gastroenterology. 1975; 68(5 Pt 1):1169-76. View

Nehra V, Bruce B, Pemberton J, Camilleri M . Psychological disorders in patients with evacuation disorders and constipation in a tertiary practice. Am J Gastroenterol. 2000; 95(7):1755-8. DOI: 10.1111/j.1572-0241.2000.02184.x. View

Chaussade S, Khyari A, Roche H, Garret M, Gaudric M, Couturier D . Determination of total and segmental colonic transit time in constipated patients. Results in 91 patients with a new simplified method. Dig Dis Sci. 1989; 34(8):1168-72. DOI: 10.1007/BF01537263. View

Jenssen T, Burhol P, Jorde R, Florholmen J, Lygren I . Radioimmunoassayable plasma motilin in man. Secretagogues, insulin-induced suppression, renal removal, and plasma components. Scand J Gastroenterol. 1984; 19(6):717-23. View

Glia A, Lindberg G . Quality of life in patients with different types of functional constipation. Scand J Gastroenterol. 1997; 32(11):1083-9. DOI: 10.3109/00365529709002985. View

10.

Preston D, Adrian T, Christofides N, Lennard-Jones J, Bloom S . Positive correlation between symptoms and circulating motilin, pancreatic polypeptide and gastrin concentrations in functional bowel disorders. Gut. 1985; 26(10):1059-64. PMC: 1432940. DOI: 10.1136/gut.26.10.1059. View

11.

Higgins P, Johanson J . Epidemiology of constipation in North America: a systematic review. Am J Gastroenterol. 2004; 99(4):750-9. DOI: 10.1111/j.1572-0241.2004.04114.x. View

12.

Pare P, Ferrazzi S, Thompson W, Irvine E, Rance L . An epidemiological survey of constipation in canada: definitions, rates, demographics, and predictors of health care seeking. Am J Gastroenterol. 2001; 96(11):3130-7. DOI: 10.1111/j.1572-0241.2001.05259.x. View

13.

Mason H, Kamm M . Psychological morbidity in women with idiopathic constipation. Am J Gastroenterol. 2000; 95(10):2852-7. DOI: 10.1111/j.1572-0241.2000.02313.x. View

14.

Simren M, Bjornsson E, Abrahamsson H . High interdigestive and postprandial motilin levels in patients with the irritable bowel syndrome. Neurogastroenterol Motil. 2005; 17(1):51-7. DOI: 10.1111/j.1365-2982.2004.00582.x. View

15.

Sirica A . Cholangiocarcinoma: molecular targeting strategies for chemoprevention and therapy. Hepatology. 2005; 41(1):5-15. DOI: 10.1002/hep.20537. View

16.

Heaton K, Cripps H . Straining at stool and laxative taking in an English population. Dig Dis Sci. 1993; 38(6):1004-8. DOI: 10.1007/BF01295713. View

17.

Drossman D . The functional gastrointestinal disorders and the Rome II process. Gut. 1999; 45 Suppl 2:II1-5. PMC: 1766692. DOI: 10.1136/gut.45.2008.ii1. View

18.

Stewart W, Liberman J, Sandler R, Woods M, Stemhagen A, Chee E . Epidemiology of constipation (EPOC) study in the United States: relation of clinical subtypes to sociodemographic features. Am J Gastroenterol. 1999; 94(12):3530-40. DOI: 10.1111/j.1572-0241.1999.01642.x. View

19.

Harrington K, Haskvitz E . Managing a patient's constipation with physical therapy. Phys Ther. 2006; 86(11):1511-9. DOI: 10.2522/ptj.20050347. View

20.

Metcalf A, Phillips S, Zinsmeister A, MacCarty R, Beart R, Wolff B . Simplified assessment of segmental colonic transit. Gastroenterology. 1987; 92(1):40-7. DOI: 10.1016/0016-5085(87)90837-7. View