A Journey Through the Microscopic Ages of DNA Replication

Overview

Journal Protoplasma

Publisher Springer

Specialty Biology

Date 2016 Dec 13

PMID 27943022

Citations 4

Authors

Marius Reinhart

M Cristina Cardoso

Affiliations

Soon will be listed here.

Abstract

Scientific discoveries and technological advancements are inseparable but not always take place in a coherent chronological manner. In the next, we will provide a seemingly unconnected and serendipitous series of scientific facts that, in the whole, converged to unveil DNA and its duplication. We will not cover here the many and fundamental contributions from microbial genetics and in vitro biochemistry. Rather, in this journey, we will emphasize the interplay between microscopy development culminating on super resolution fluorescence microscopy (i.e., nanoscopy) and digital image analysis and its impact on our understanding of DNA duplication. We will interlace the journey with landmark concepts and experiments that have brought the cellular DNA replication field to its present state.

Citing Articles

DeOri 10.0: An Updated Database of Experimentally Identified Eukaryotic Replication Origins.

Zeng Y, Yin Z, Luo H, Gao F Genomics Proteomics Bioinformatics. 2024; 22(5).

PMID: 39404857 PMC: 11652270. DOI: 10.1093/gpbjnl/qzae076.

Developmental differences in genome replication program and origin activation.

Rausch C, Weber P, Prorok P, Horl D, Maiser A, Lehmkuhl A Nucleic Acids Res. 2020; 48(22):12751-12777.

PMID: 33264404 PMC: 7736824. DOI: 10.1093/nar/gkaa1124.

Snapshots of archaeal DNA replication and repair in living cells using super-resolution imaging.

Delpech F, Collien Y, Mahou P, Beaurepaire E, Myllykallio H, Lestini R Nucleic Acids Res. 2018; 46(20):10757-10770.

PMID: 30212908 PMC: 6237752. DOI: 10.1093/nar/gky829.

Editorial.

Stick R, Draber P Protoplasma. 2017; 254(3):1141-1142.

PMID: 28299513 DOI: 10.1007/s00709-017-1093-0.

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