One Gene, Two Paracellular Ion Channels-claudin-10 in the Kidney

Overview

Journal Pflugers Arch

Specialty Physiology

Date 2016 Dec 13

PMID 27942952

Citations 17

Authors

Susanne Milatz

Tilman Breiderhoff

Affiliations

Soon will be listed here.

Abstract

Claudins are tight junction membrane proteins and regulate the paracellular passage of ions and water. They can seal the paracellular cleft against solute passage but also form paracellular channels. They are tetraspan proteins with two extracellular segments. Claudin-10 exists in at least two functional isoforms, claudin-10a and claudin-10b, that differ in their first transmembrane segment and first extracellular segment. Both isoforms act as selective paracellular ion channels, either for anions (claudin-10a) or for cations (claudin-10b). Their diverse functions are reflected in completely different expression patterns in the body, especially in the kidney. Their structural and functional similarities and differences make them ideal subjects to study determinants of claudin charge selectivity and pore formation. This review aims to summarise research on permeability properties of the claudin-10 channels and their role in physiology and pathophysiology of the kidney.

Citing Articles

Ion and water permeation through claudin-10b and claudin-15 paracellular channels.

Berselli A, Alberini G, Benfenati F, Maragliano L Comput Struct Biotechnol J. 2024; 23:4177-4191.

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Tight junction and kidney stone disease.

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Tooth Formation as Experimental Model to Study Chemotherapy on Tissue Development: Effect of a Specific Dose of Temozolomide/Veliparib.

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Defective claudin-10 causes a novel variation of HELIX syndrome through compromised tight junction strand assembly.

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