Estimation of Saliva Cotinine Cut-Off Points for Active and Passive Smoking During Pregnancy-Polish Mother and Child Cohort (REPRO_PL)

Overview

Journal Int J Environ Res Public Health

Publisher MDPI

Specialties Environmental Health
Public Health

Date 2016 Dec 13

PMID 27941658

Citations 17

Authors

Kinga Polanska

Anna Krol

Pawel Kaluzny

Danuta Ligocka

Karolina Mikolajewska

Seif Shaheen

Robert Walton

Wojciech Hanke

Affiliations

Soon will be listed here.

Abstract

A reliable assessment of smoking status has significant public health implications and is essential for research purposes. The aim of this study was to determine optimal saliva cotinine cut-off values for smoking during pregnancy. The analyses were based on data from 1771 women from the Polish Mother and Child Cohort. Saliva cotinine concentrations were assessed by high performance liquid chromatography coupled with tandem mass spectrometry (HPLC-ESI + MS/MS). The saliva cotinine cut-off value for active smoking was established at 10 ng/mL (sensitivity 96%, specificity 95%) and for passive smoking at 1.5 ng/mL (sensitivity 63%, specificity 71%). About 5% of the self-reported non-smoking women were classified as smokers based on the cotinine cut-off value. Significantly more younger, single, and less educated self-reported non-smokers had a cotinine concentration higher than 10 ng/mL compared to those who were older, married, and who had a university degree. Close to 30% of the non-smokers who indicated that smoking was not allowed in their home could be classified as exposed to passive smoking based on the cut-off value. The study suggests that self-reported smoking status is a valid measure of active smoking, whereas in the case of passive smoking, a combination of questionnaire data and biomarker verification may be required.

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References

Stragierowicz J, Mikolajewska K, Zawadzka-Stolarz M, Polanska K, Ligocka D . Estimation of cutoff values of cotinine in urine and saliva for pregnant women in Poland. Biomed Res Int. 2013; 2013:386784. PMC: 3818804. DOI: 10.1155/2013/386784. View

. Biochemical verification of tobacco use and cessation. Nicotine Tob Res. 2002; 4(2):149-59. DOI: 10.1080/14622200210123581. View

Coleman T, Chamberlain C, Davey M, Cooper S, Leonardi-Bee J . Pharmacological interventions for promoting smoking cessation during pregnancy. Cochrane Database Syst Rev. 2012; (9):CD010078. DOI: 10.1002/14651858.CD010078. View

Zielinska-Danch W, Wardas W, Sobczak A, Szoltysek-Boldys I . Estimation of urinary cotinine cut-off points distinguishing non-smokers, passive and active smokers. Biomarkers. 2007; 12(5):484-96. DOI: 10.1080/13547500701421341. View

Benowitz N . Cotinine as a biomarker of environmental tobacco smoke exposure. Epidemiol Rev. 1996; 18(2):188-204. DOI: 10.1093/oxfordjournals.epirev.a017925. View

Smith J, Robinson R, Khan B, Sosnoff C, Dillard D . Estimating cotinine associations and a saliva cotinine level to identify active cigarette smoking in alaska native pregnant women. Matern Child Health J. 2013; 18(1):120-128. PMC: 5664941. DOI: 10.1007/s10995-013-1241-x. View

Avila-Tang E, Al-Delaimy W, Ashley D, Benowitz N, Bernert J, Kim S . Assessing secondhand smoke using biological markers. Tob Control. 2012; 22(3):164-71. PMC: 3639350. DOI: 10.1136/tobaccocontrol-2011-050298. View

Benowitz N . Biomarkers of environmental tobacco smoke exposure. Environ Health Perspect. 1999; 107 Suppl 2:349-55. PMC: 1566286. DOI: 10.1289/ehp.99107s2349. View

Polanska K, Hanke W, Gromadzinska J, Ligocka D, Gulczynska E, Sobala W . Polish mother and child cohort study--defining the problem, the aim of the study and methodological assumption. Int J Occup Med Environ Health. 2010; 22(4):383-91. DOI: 10.2478/v10001-009-0037-0. View

10.

Sasaki S, Braimoh T, Yila T, Yoshioka E, Kishi R . Self-reported tobacco smoke exposure and plasma cotinine levels during pregnancy--a validation study in Northern Japan. Sci Total Environ. 2011; 412-413:114-8. DOI: 10.1016/j.scitotenv.2011.10.019. View

11.

Dempsey D, Jacob 3rd P, Benowitz N . Accelerated metabolism of nicotine and cotinine in pregnant smokers. J Pharmacol Exp Ther. 2002; 301(2):594-8. DOI: 10.1124/jpet.301.2.594. View

12.

Coleman T, Chamberlain C, Davey M, Cooper S, Leonardi-Bee J . Pharmacological interventions for promoting smoking cessation during pregnancy. Cochrane Database Syst Rev. 2015; (12):CD010078. DOI: 10.1002/14651858.CD010078.pub2. View

13.

Etzel R . A review of the use of saliva cotinine as a marker of tobacco smoke exposure. Prev Med. 1990; 19(2):190-7. DOI: 10.1016/0091-7435(90)90020-k. View

14.

Kaufman F, Kharrazi M, Delorenze G, Eskenazi B, Bernert J . Estimation of environmental tobacco smoke exposure during pregnancy using a single question on household smokers versus serum cotinine. J Expo Anal Environ Epidemiol. 2002; 12(4):286-95. DOI: 10.1038/sj.jea.7500224. View

15.

Kvalvik L, Nilsen R, Skjaerven R, Vollset S, Midttun O, Ueland P . Self-reported smoking status and plasma cotinine concentrations among pregnant women in the Norwegian Mother and Child Cohort Study. Pediatr Res. 2012; 72(1):101-7. PMC: 3630336. DOI: 10.1038/pr.2012.36. View

16.

Goniewicz M, Zielinska-Danch W . Electronic cigarette use among teenagers and young adults in Poland. Pediatrics. 2012; 130(4):e879-85. DOI: 10.1542/peds.2011-3448. View

17.

Rebagliato M, Bolumar F, du V Florey C, Jarvis M, Perez-Hoyos S, Hernandez-Aguado I . Variations in cotinine levels in smokers during and after pregnancy. Am J Obstet Gynecol. 1998; 178(3):568-71. DOI: 10.1016/s0002-9378(98)70440-5. View

18.

Boyd N, Windsor R, Perkins L, Lowe J . Quality of measurement of smoking status by self-report and saliva cotinine among pregnant women. Matern Child Health J. 2000; 2(2):77-83. DOI: 10.1023/a:1022936705438. View

19.

Benowitz N, Bernert J, Caraballo R, Holiday D, Wang J . Optimal serum cotinine levels for distinguishing cigarette smokers and nonsmokers within different racial/ethnic groups in the United States between 1999 and 2004. Am J Epidemiol. 2008; 169(2):236-48. DOI: 10.1093/aje/kwn301. View

20.

Robin X, Turck N, Hainard A, Tiberti N, Lisacek F, Sanchez J . pROC: an open-source package for R and S+ to analyze and compare ROC curves. BMC Bioinformatics. 2011; 12:77. PMC: 3068975. DOI: 10.1186/1471-2105-12-77. View