Anxiety Symptoms and Disorders Among Adults Living with HIV and AIDS: A Critical Review and Integrative Synthesis of the Empirical Literature

Overview

Journal Clin Psychol Rev

Specialty Psychology

Date 2016 Dec 13

PMID 27939443

Citations 79

Authors

Charles Brandt

Michael J Zvolensky

Steven P Woods

Adam Gonzalez

Steven A Safren

Conall M OCleirigh

Affiliations

Soon will be listed here.

Abstract

There are over 35 million people worldwide infected with the Human Immunodeficiency Virus (HIV) and its progression to Acquired Immunodeficiency Syndrome (AIDS; WHO, 2014). With the advent of combined antiretroviral therapy (i.e., cART) in 1996, persons living with HIV/AIDS (PLWHA) now have much longer life expectancies. However, living with HIV remains challenging, as it is associated with a number of significant and recurrent (chronic) stressors including physical pain, side effects of cART, social stigma, and discrimination, among other social stressors. Presumably, as a result of these types of stressors, a disproportionately high number of PLWHA struggle with clinically-significant psychiatric symptoms and disorders. Although much scientific and clinical attention has focused on depressed mood and psychopathology among PLWHA, there has been comparably less focus on anxiety and its disorders. The paucity of work in this area is concerning from a public health perspective, as anxiety symptoms and disorders are the most common class of psychiatric disorders and often maintain a large negative impact on life functioning.

Citing Articles

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References

Lewis G, Pelosi A, Araya R, Dunn G . Measuring psychiatric disorder in the community: a standardized assessment for use by lay interviewers. Psychol Med. 1992; 22(2):465-86. DOI: 10.1017/s0033291700030415. View

OCleirigh C, Magidson J, Skeer M, Mayer K, Safren S . Prevalence of Psychiatric and Substance Abuse Symptomatology Among HIV-Infected Gay and Bisexual Men in HIV Primary Care. Psychosomatics. 2015; 56(5):470-8. PMC: 4339664. DOI: 10.1016/j.psym.2014.08.004. View

Hansen N, Harrison B, Fambro S, Bodnar S, Heckman T, Sikkema K . The structure of coping among older adults living with HIV/AIDS and depressive symptoms. J Health Psychol. 2012; 18(2):198-211. PMC: 3653185. DOI: 10.1177/1359105312440299. View

Wu A, Hays R, Kelly S, Malitz F, Bozzette S . Applications of the Medical Outcomes Study health-related quality of life measures in HIV/AIDS. Qual Life Res. 1997; 6(6):531-54. DOI: 10.1023/a:1018460132567. View

Waldrop-Valverde D, Valverde E . Homelessness and psychological distress as contributors to antiretroviral nonadherence in HIV-positive injecting drug users. AIDS Patient Care STDS. 2005; 19(5):326-34. DOI: 10.1089/apc.2005.19.326. View

Ingersoll K . The impact of psychiatric symptoms, drug use, and medication regimen on non-adherence to HIV treatment. AIDS Care. 2003; 16(2):199-211. DOI: 10.1080/09540120410001641048. View

Zvolensky M, Kotov R, Antipova A, Schmidt N . Cross cultural evaluation of smokers risk for panic and anxiety pathology: a test in a Russian epidemiological sample. Behav Res Ther. 2003; 41(10):1199-215. DOI: 10.1016/s0005-7967(03)00031-7. View

Rapee R, Medoro L . Fear of physical sensations and trait anxiety as mediators of the response to hyperventilation in nonclinical subjects. J Abnorm Psychol. 1994; 103(4):693-9. DOI: 10.1037//0021-843x.103.4.693. View

Sewell M, Goggin K, Rabkin J, Ferrando S, McElhiney M, Evans S . Anxiety syndromes and symptoms among men with AIDS: a longitudinal controlled study. Psychosomatics. 2000; 41(4):294-300. DOI: 10.1176/appi.psy.41.4.294. View

10.

Carrieri M, Chesney M, Spire B, Loundou A, Sobel A, Lepeu G . Failure to maintain adherence to HAART in a cohort of French HIV-positive injecting drug users. Int J Behav Med. 2003; 10(1):1-14. DOI: 10.1207/s15327558ijbm1001_01. View

11.

Saunders J, Aasland O, Babor T, De la Fuente J, Grant M . Development of the Alcohol Use Disorders Identification Test (AUDIT): WHO Collaborative Project on Early Detection of Persons with Harmful Alcohol Consumption--II. Addiction. 1993; 88(6):791-804. DOI: 10.1111/j.1360-0443.1993.tb02093.x. View

12.

Hurst N, Ruta D, Kind P . Comparison of the MOS short form-12 (SF12) health status questionnaire with the SF36 in patients with rheumatoid arthritis. Br J Rheumatol. 1998; 37(8):862-9. DOI: 10.1093/rheumatology/37.8.862. View

13.

Compas B, Wadsworth M, Thomsen A, SALTZMAN H . Responses to stress in adolescence: measurement of coping and involuntary stress responses. J Consult Clin Psychol. 2001; 68(6):976-92. View

14.

Schmidt N, Richey J, Fitzpatrick K . Discomfort intolerance: Development of a construct and measure relevant to panic disorder. J Anxiety Disord. 2006; 20(3):263-80. DOI: 10.1016/j.janxdis.2005.02.002. View

15.

Gross J . Antecedent- and response-focused emotion regulation: divergent consequences for experience, expression, and physiology. J Pers Soc Psychol. 1998; 74(1):224-37. DOI: 10.1037//0022-3514.74.1.224. View

16.

Leyro T, Vujanovic A, Bonn-Miller M . Examining associations between cognitive-affective vulnerability and HIV symptom severity, perceived barriers to treatment adherence, and viral load among HIV-positive adults. Int J Behav Med. 2014; 22(1):139-48. DOI: 10.1007/s12529-014-9404-8. View

17.

Krueger R . The structure of common mental disorders. Arch Gen Psychiatry. 1999; 56(10):921-6. DOI: 10.1001/archpsyc.56.10.921. View

18.

Pence B, Gaynes B, Whetten K, Eron Jr J, Ryder R, Miller W . Validation of a brief screening instrument for substance abuse and mental illness in HIV-positive patients. J Acquir Immune Defic Syndr. 2005; 40(4):434-44. DOI: 10.1097/01.qai.0000177512.30576.9c. View

19.

Kelly J, Murphy D . Psychological interventions with AIDS and HIV: prevention and treatment. J Consult Clin Psychol. 1992; 60(4):576-85. DOI: 10.1037//0022-006x.60.4.576. View

20.

Gonzalez A, Zvolensky M, Parent J, Grover K, Hickey M . HIV symptom distress and anxiety sensitivity in relation to panic, social anxiety, and depression symptoms among HIV-positive adults. AIDS Patient Care STDS. 2012; 26(3):156-64. DOI: 10.1089/apc.2011.0309. View