Genetics and Pathogenesis of Idiopathic Scoliosis

Overview

Journal Scoliosis Spinal Disord

Date 2016 Dec 10

PMID 27933320

Citations 30

Authors

A Grauers

E Einarsdottir

P Gerdhem

Affiliations

Soon will be listed here.

Abstract

Idiopathic scoliosis (IS), the most common spinal deformity, affects otherwise healthy children and adolescents during growth. The aetiology is still unknown, although genetic factors are believed to be important. The present review corroborates the understanding of IS as a complex disease with a polygenic background. Presumably IS can be due to a spectrum of genetic risk variants, ranging from very rare or even private to very common. The most promising candidate genes are highlighted.

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