Osteoblast and Stem Cell Response to Nanoscale Topographies: a Review

Overview

Journal Sci Technol Adv Mater

Specialty Biomedical Engineering

Date 2016 Dec 10

PMID 27933112

Citations 4

Authors

Nur Izzati Aminuddin

Roslina Ahmad

Sheikh Ali Akbar

Belinda Pingguan-Murphy

Affiliations

Soon will be listed here.

Abstract

To understand how cells respond to the nanoscale extracellular environment , cells from various sources have been cultured on nanoscale patterns fabricated using bottom-up and top-down techniques. Human fetal osteoblasts (hFOBs) and stem cells are some of them and they are known to be overtly responsive to nanoscale topographies - allowing us to investigate the hows and whys of the response . Information gathered from these studies could be used to control the cells, i.e. make the stem cells differentiate or retain their characteristics without the use of medium supplements. In this review, hFOB and stem cell responses to nanotopographies are summarized and discussed to shed some light on the influence of patterns on the reactions. Although both types of cells are responsive to nanoscale topographies, the responses are found to be unique to topographical dimension, shape, orientation and the types of cells used. This implies that cellular responses are influenced by multitude of factors and that if done right, cheaper self-assembled nanotopographies can be tailored to control the cells. A new self-assembly, powder-based technique is also included to provide an insight into the future of nanofabrication.

Citing Articles

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