The Shark Alar Hypothalamus: Molecular Characterization of Prosomeric Subdivisions and Evolutionary Trends

Overview

Journal Front Neuroanat

Date 2016 Dec 10

PMID 27932958

Citations 7

Authors

Gabriel N Santos-Duran

Susana Ferreiro-Galve

Arnaud Menuet

Idoia Quintana-Urzainqui

Sylvie Mazan

Isabel Rodriguez-Moldes

Eva Candal

Affiliations

Soon will be listed here.

Abstract

The hypothalamus is an important physiologic center of the vertebrate brain involved in the elaboration of individual and species survival responses. To better understand the ancestral organization of the alar hypothalamus we revisit previous data on , , , 1 expression and Pax6 immunoreactivity jointly with new data on , , , and expression, in addition to immunoreactivity to serotonin (5-HT) and doublecortin (DCX) in the catshark , a key species for this purpose since cartilaginous fishes are basal representatives of gnathostomes (jawed vertebrates). Our study revealed a complex genoarchitecture for the chondrichthyan alar hypothalamus. We identified terminal (rostral) and peduncular (caudal) subdivisions in the prosomeric paraventricular and subparaventricular areas (TPa/PPa and TSPa/PSPa, respectively) evidenced by the expression pattern of developmental genes like (TPa) and immunoreactivity against Pax6 (PSPa) and 5-HT (PPa and PSPa). Dorso-ventral subdivisions were only evidenced in the SPa (SPaD, SPaV; respectively) by means of Pax6 and (respectively). Interestingly, expression overlaps over the alar-basal boundary, as does in other vertebrates. Our results reveal evidences for the existence of different groups of tangentially migrated cells expressing , , and . The genoarchitectonic comparative analysis suggests alternative interpretations of the rostral-most alar plate in prosomeric terms and reveals a conserved molecular background for the vertebrate alar hypothalamus likely acquired before/during the agnathan-gnathostome transition, on which , , , and are expressed in the Pa while and 8 are expressed in the SPa.

Citing Articles

Developmental genoarchitectonics as a key tool to interpret the mature anatomy of the chondrichthyan hypothalamus according to the prosomeric model.

Santos-Duran G, Ferreiro-Galve S, Mazan S, Anadon R, Rodriguez-Moldes I, Candal E Front Neuroanat. 2022; 16:901451.

PMID: 35991967 PMC: 9385951. DOI: 10.3389/fnana.2022.901451.

Distinct Subdivisions in the Transition Between Telencephalon and Hypothalamus Produce Otp and Sim1 Cells for the Extended Amygdala in Sauropsids.

Metwalli A, Abellan A, Freixes J, Pross A, Desfilis E, Medina L Front Neuroanat. 2022; 16:883537.

PMID: 35645737 PMC: 9133795. DOI: 10.3389/fnana.2022.883537.

Prosomeric Hypothalamic Distribution of Tyrosine Hydroxylase Positive Cells in Adolescent Rats.

Bilbao M, Garrigos D, Martinez-Morga M, Toval A, Kutsenko Y, Bautista R Front Neuroanat. 2022; 16:868345.

PMID: 35601999 PMC: 9121318. DOI: 10.3389/fnana.2022.868345.

Developmental Genes and Malformations in the Hypothalamus.

Diaz C, Puelles L Front Neuroanat. 2020; 14:607111.

PMID: 33324176 PMC: 7726113. DOI: 10.3389/fnana.2020.607111.

Conserved Genoarchitecture of the Basal Hypothalamus in Zebrafish Embryos.

Schredelseker T, Driever W Front Neuroanat. 2020; 14:3.

PMID: 32116574 PMC: 7016197. DOI: 10.3389/fnana.2020.00003.

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