Relation Between Amniotic Fluid Infection or Cytokine Levels and Hearing Screen Failure in Infants at 32 Wk Gestation or Less

Overview

Journal Pediatr Res

Specialties Biology
Pediatrics

Date 2016 Dec 8

PMID 27925622

Citations 10

Authors

Eun Young Jung

Byung Yoon Choi

Jihye Rhee

JaeHong Park

Soo-Hyun Cho

Kyo Hoon Park

Affiliations

Soon will be listed here.

Abstract

Background: To determine whether the presence of intra-amniotic infection and elevated proinflammatory cytokine levels in amniotic fluid (AF) are associated with failure in the newborn hearing screen (NHS) test in very preterm neonates.

Methods: This is a retrospective cohort study of 112 premature singleton neonates born to women with preterm labor or preterm premature rupture of membranes at ≤32 wk. AF obtained through amniocentesis was cultured, and interleukin-6 (IL-6) and IL-8 levels were determined.

Results: Fourteen (12.5%) neonates failed the NHS test. The prevalence of a positive AF culture was 40% (45/112). Multiple logistic regression analyses indicated that intra-amniotic infection was significantly associated with failure in the NHS test after adjusting for baseline covariates such as maternal white blood cell count (WBC) and periventricular leukomalacia. However, the IL-6 and IL-8 levels in AF were not significantly associated with hearing screen failure. Moreover, neither gestational age at birth nor birth weight was associated with NHS failure.

Conclusion: The presence of intra-amniotic infection, but not elevated levels of AF IL-6 and IL-8, may contribute to the risk for failure in the NHS test in very preterm neonates. This finding suggests that intra-amniotic infection in utero might contribute to the development of congenital sensorineural hearing loss.

Citing Articles

Plasma acute phase proteins as potential predictors of intra-amniotic inflammation and infection in preterm premature rupture of membranes.

Cho H, Park K, Oh E, Lee M, Choi B, Im E Innate Immun. 2024; :17534259241306237.

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Rescue Cerclage in Women With Acute Cervical Insufficiency and Intra-Amniotic Inflammation: A Retrospective Cohort Study.

Park K, Lee K, Choi B, Lee M, Jeong D J Korean Med Sci. 2024; 39(42):e310.

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Predictive potential of various plasma inflammation-, angiogenesis-, and extracellular matrix remodeling-associated mediators for intra-amniotic inflammation and/or microbial invasion of the amniotic cavity in preterm labor.

Joo E, Hong S, Park K, Kim H, Lee M, Shin S Arch Gynecol Obstet. 2024; 310(1):413-426.

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Proteomic analysis of plasma to identify novel biomarkers for intra-amniotic infection and/or inflammation in preterm premature rupture of membranes.

Back J, Kim S, Gu M, Kim H, Lee K, Lee J Sci Rep. 2023; 13(1):5658.

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Cord blood transforming growth factor-β-induced as predictive biomarker of retinopathy of prematurity in preterm infants.

Song J, Woo S, Park K, Joo E, Kim H, Oh E Graefes Arch Clin Exp Ophthalmol. 2023; 261(9):2477-2488.

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