An Optimal Wilcoxon-Mann-Whitney Test of Mortality and a Continuous Outcome

Overview

Journal Stat Methods Med Res

Publisher Sage Publications

Specialties Public Health
Science

Date 2016 Dec 7

PMID 27920364

Citations 10

Authors

Roland A Matsouaka

Aneesh B Singhal

Rebecca A Betensky

Affiliations

Soon will be listed here.

Abstract

We consider a two-group randomized clinical trial, where mortality affects the assessment of a follow-up continuous outcome. Using the worst-rank composite endpoint, we develop a weighted Wilcoxon-Mann-Whitney test statistic to analyze the data. We determine the optimal weights for the Wilcoxon-Mann-Whitney test statistic that maximize its power. We derive a formula for its power and demonstrate its accuracy in simulations. Finally, we apply the method to data from an acute ischemic stroke clinical trial of normobaric oxygen therapy.

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