Extra-tongue Oral Granular Cell Tumor: Histological and Immunohistochemical Aspect

Overview

Journal Med Oral Patol Oral Cir Bucal

Specialty Dentistry

Date 2016 Dec 6

PMID 27918739

Citations 6

Authors

P-L Tobouti

F-M Pigatti

M-C Martins-Mussi

B-T Sedassari

S-C Orsini-Machado de Sousa

Affiliations

Soon will be listed here.

Abstract

Background: Granular cell tumor (GCT) is an uncommon benign tumor founded in any part of the body but mainly in the tongue. Extra-tongue oral granular cell tumor (ETOGCT) is rare with few cases reported. Here we describe seven cases of oral GCT located in sites other then the tongue and discuss histopathological and immunohistochemical differences between differential diagnoses.

Material And Methods: We retrieved all cases diagnosed with oral granular cell tumor, from the Oral Pathology Service at the School of Dentistry/ University of São Paulo, and excluded the ones sited in the tongue. Immunohistochemical staining anti-S100 was also performed.

Results: The presented cases of Extra-tongue Oral Granular Cell Tumor (ETOGT) are composed by granular cells with intimately association with the adjacent tissue. Atypia and mitoses were not seen, and in most cases, the typical pseudoepitheliomatous hyperplasia was not observed.

Conclusions: The importance of an adequate attention is to avoid misdiagnoses, since ETOGT is rare and the tricking histopathological findings could induce to it. All the cases can be differentiated from the tumors that has a granular cell proliferation through a morphological analysis and when needed, immunohistochemistry stain.

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References

Gayen T, Das A, Shome K, Bandyopadhyay D, Das D, Saha A . Granular Cell Tumor: An Uncommon Benign Neoplasm. Indian J Dermatol. 2015; 60(3):322. PMC: 4458968. DOI: 10.4103/0019-5154.156453. View

Bhattacharyya I, Summerlin D, Cohen D, Ellis G, Bavitz J, Gillham L . Granular cell leiomyoma of the oral cavity. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006; 102(3):353-9. DOI: 10.1016/j.tripleo.2005.08.005. View

Vered M, Carpenter W, Buchner A . Granular cell tumor of the oral cavity: updated immunohistochemical profile. J Oral Pathol Med. 2009; 38(1):150-9. DOI: 10.1111/j.1600-0714.2008.00725.x. View

Park J, Do N, Cho S, Choi J . Granular cell tumor on larynx. Clin Exp Otorhinolaryngol. 2010; 3(1):52-5. PMC: 2848320. DOI: 10.3342/ceo.2010.3.1.52. View

Dive A, Dhobley A, Fande P, Dixit S . Granular cell tumor of the tongue: Report of a case. J Oral Maxillofac Pathol. 2013; 17(1):148. PMC: 3687175. DOI: 10.4103/0973-029X.110728. View

Souza A, de Araujo V, Santos F, Martinez E, de Menezes Filho J, de Araujo N . Intraoral adult rhabdomyoma: a case report. Case Rep Dent. 2013; 2013:741548. PMC: 3833031. DOI: 10.1155/2013/741548. View

El-Gamal H, Robinson-Bostom L, Saddler K, Pan T, Mihm M . Compound melanocytic nevi with granular cell changes. J Am Acad Dermatol. 2004; 50(5):765-6. DOI: 10.1016/j.jaad.2003.11.068. View

Aparna H, Jayanth B, Shashidara R, Jaishankar P . Congenital epulis in a newborn: a case report, immunoprofiling and review of literature. Ethiop J Health Sci. 2014; 24(4):359-62. PMC: 4248036. DOI: 10.4314/ejhs.v24i4.12. View

Boulos R, Marsot-Dupuch K, Meyer B, Tran Ba Huy P . Granular cell tumor of the palate: a case report. AJNR Am J Neuroradiol. 2002; 23(5):850-4. PMC: 7974728. View

10.

Andrade E, Laureano Filho J, Rocha N, Pita Neto I, Camargo I . Isolated intra-oral granular cell tumor: report of two cases and review of the literature. Acta Odontol Latinoam. 2010; 23(2):99-104. View

11.

Nikitakis N, Tzerbos F, Triantafyllou K, Papadimas C, Sklavounou A . Granular cell ameloblastoma: an unusual histological subtype report and review of literature. J Oral Maxillofac Res. 2014; 1(4):e3. PMC: 3886069. DOI: 10.5037/jomr.2010.1403. View

12.

Shintaku M . Immunohistochemical localization of autophagosomal membrane-associated protein LC3 in granular cell tumor and schwannoma. Virchows Arch. 2011; 459(3):315-9. PMC: 3162629. DOI: 10.1007/s00428-011-1104-z. View

13.

An S, Jang J, Min K, Kim M, Park H, Park Y . Granular cell tumor of the gastrointestinal tract: histologic and immunohistochemical analysis of 98 cases. Hum Pathol. 2015; 46(6):813-9. DOI: 10.1016/j.humpath.2015.02.005. View

14.

Bang K, Bodhade A, Dive A . Congenital granular cell epulis of a newborn. Dent Res J (Isfahan). 2013; 9(Suppl 1):S136-8. PMC: 3692194. View

15.

Elinav E, Nowarski R, Thaiss C, Hu B, Jin C, Flavell R . Inflammation-induced cancer: crosstalk between tumours, immune cells and microorganisms. Nat Rev Cancer. 2013; 13(11):759-71. DOI: 10.1038/nrc3611. View

16.

Eghbalian F, Monsef A . Congenital epulis in the newborn, review of the literature and a case report. J Pediatr Hematol Oncol. 2009; 31(3):198-9. DOI: 10.1097/MPH.0b013e31818ab2f7. View

17.

Chakrabarti I, Basu A, Ghosh N . Oncocytic lesion of parotid gland: A dilemma for cytopathologists. J Cytol. 2012; 29(1):80-2. PMC: 3307464. DOI: 10.4103/0970-9371.93236. View

18.

Mori O, Hachisuka H, Sakamoto F, Nomura H, Sasai Y . Immunohistochemical observation of S-100 protein and neuron specific enolase in the tumour cells of granular cell tumour. Acta Histochem. 1988; 83(1):33-8. DOI: 10.1016/S0065-1281(88)80068-0. View

19.

Nagaraj P, Ongole R, Bhujanga-Rao B . Granular cell tumor of the tongue in a 6-year-old girl--a case report. Med Oral Patol Oral Cir Bucal. 2006; 11(2):E162-4. View

20.

Pastuszak A, Schuler L, Speck-Martins C, Coelho K, Cordello S, Vargas F . Use of misoprostol during pregnancy and Möbius' syndrome in infants. N Engl J Med. 1998; 338(26):1881-5. DOI: 10.1056/NEJM199806253382604. View