Bone Mineral Density of Extremities is Associated with Coronary Calcification and Biopsy-verified Vascular Calcification in Living-donor Renal Transplant Recipients

Overview

Journal J Bone Miner Metab

Specialty Endocrinology

Date 2016 Dec 4

PMID 27913900

Citations 7

Authors

Zhimin Chen

Jia Sun

Mathias Haarhaus

Peter Barany

Lars Wennberg

Jonaz Ripsweden

Torkel B Brismar

Bengt Lindholm

Annika Wernerson

Magnus Soderberg

Peter Stenvinkel

Abdul Rashid Qureshi

Affiliations

Soon will be listed here.

Abstract

Chronic kidney disease (CKD) mineral and bone disorders (CKD-MBD) may lead to low bone mineral density (BMD) and vascular calcification (VC), but links to the latter are unclear. Here we investigated associations between BMD, coronary artery calcium (CAC) scores, and histological signs of VC in end-stage renal disease (ESRD) patients undergoing living-donor kidney transplantation (LD-Rtx). In 66 ESRD patients (median age 45 years, 68% males), BMD (by dual-energy X-ray absorptiometry, DXA), CAC score (by computed tomography, CT; n = 54), and degree of VC score (graded by histological examination of epigastric artery specimens collected at LD-Rtx; n = 55) were assessed at the time of LD-Rtx. Of the patients, 26% had osteopenia and 7% had osteoporosis. Of those undergoing artery biopsy, 16% had extensive VC, and of those undergoing CT 28% had high CAC score (>100 Agatston units). CAC scores correlated with BMD of legs and pelvis. BMDs of leg and pelvic sub-regions were significantly lower in patients with extensive VC. In multivariate regression analysis adjusted for age and gender, lower BMD of leg sub-region was associated with CAC score >100 AUs and extensive VC, and patients with extensive VC had significantly higher CAC score. Both high CAC and extensive VC were independently predicted by low BMD of legs. Low BMD has the potential to identify ESRD patients at risk of vascular calcification.

Citing Articles

Vascular calcification progression and its association with mineral and bone disorder in kidney transplant recipients.

Sun L, Huang Z, Fei S, Ni B, Wang Z, Chen H Ren Fail. 2023; 45(2):2276382.

PMID: 37936391 PMC: 10653689. DOI: 10.1080/0886022X.2023.2276382.

Cardiovascular Calcification Heterogeneity in Chronic Kidney Disease.

Hutcheson J, Goettsch C Circ Res. 2023; 132(8):993-1012.

PMID: 37053279 PMC: 10097496. DOI: 10.1161/CIRCRESAHA.123.321760.

Reduction of Calciprotein Particles in Adults Receiving Infliximab for Chronic Inflammatory Disease.

Tiong M, Smith E, Toussaint N, Al-Khayyat H, Holt S JBMR Plus. 2021; 5(6):e10497.

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Sparing effect of peritoneal dialysis vs hemodialysis on BMD changes and its impact on mortality.

Iseri K, Qureshi A, Ripsweden J, Heimburger O, Barany P, Bergstrom I J Bone Miner Metab. 2020; 39(2):260-269.

PMID: 32888063 DOI: 10.1007/s00774-020-01144-8.

Bone mineral density and mortality in end-stage renal disease patients.

Iseri K, Dai L, Chen Z, Qureshi A, Brismar T, Stenvinkel P Clin Kidney J. 2020; 13(3):307-321.

PMID: 32699616 PMC: 7367137. DOI: 10.1093/ckj/sfaa089.

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