The Role of Endothelial Progenitor Cells in Transient Ischemic Attack Patients for Future Cerebrovascular Events

Overview

Journal J Res Med Sci

Specialty General Medicine

Date 2016 Dec 2

PMID 27904593

Citations 4

Authors

Rokhsareh Meamar

Hamidreza Nikyar

Leila Dehghani

Maedeh Talebi

Marzieh Dehghani

Marzieh Ghasemi

Behnaz Ansari

Mohammad Saadatnia

Affiliations

Soon will be listed here.

Abstract

Background: The role of endothelial progenitor cells (EPCs) in the maintenance of vascularization following ischemic brain after experimental stroke has been established. Accordingly, in this study, we evaluated the role of circulating EPCs in transient ischemic attack (TIA) patients for future cerebrovascular (CV) events.

Materials And Methods: The level of circulating EPCs (staining markers: CD34, CD309) were determined using flow cytometry at 24 h after TIA in thirty consecutive patients. The EPCs level was also evaluated once in thirty healthy volunteers. Over a period of 12 months, all patients were evaluated by an experienced neurologist for recurrent TIA, stroke or death induced by CV disorders.

Results: Circulating EPCs increased in patients group following the first attack of TIA when compared with controls. By analysis of covariance, cardiovascular event history, hyperlipidemia, and statin therapy remained significant independent predictors of EPCs. The mean (standard deviation) duration of follow-up was 10.5 (3.1) months (range, 2-12 months). During follow-up, a total of three patients died due to CV accident and four patients experienced again recurrent TIA. By analyzing data with Cox regression, EPC did not predict the future CV events in TIA patients.

Conclusion: Increased incidence of future CV events did not occur in those patients with elevated EPCs in the first attack of TIA. The significant predicting factors of EPCs were cardiovascular event history, hyperlipidemia, and statin therapy.

Citing Articles

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Zhao W, Zhao L, Liao J, Luo Y, He L BMC Neurol. 2019; 19(1):22.

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Mobilization of endothelial progenitor cell in patients with acute ischemic stroke.

Deng Y, Wang J, He G, Qu F, Zheng M Neurol Sci. 2017; 39(3):437-443.

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