Interaction Between C-reactive Protein and Cognitive Functions According to APOE Gene Polymorphism in Post-menopausal Women

Overview

Journal Arch Med Sci

Specialty General Medicine

Date 2016 Dec 2

PMID 27904515

Citations 4

Authors

Iwona Bojar

Mariusz Gujski

Jaroslaw Pinkas

Dorota Raczkiewicz

Alfred Owoc

Ewa Humeniuk

Affiliations

Soon will be listed here.

Abstract

Introduction: A potential factor increasing the risk of the development of cognitive impairment with age is apolipoprotein E (APOE) ε4 carrier status. A subsequent factor which may increase the risk of development of cognitive impairment at an older age is the concentration of C-reactive protein (CRP). The objective of the study was to examine the relationship between cognitive functions and the concentration of CRP in post-menopausal women who were carriers of particular apolipoprotein E gene (APOE) polymorphisms.

Material And Methods: A group of 402 women was recruited to the study. The inclusion criteria were: minimum two years after the last menstruation, follicle-stimulating hormone (FSH) concentration 30 U/ml, no dementi signs on Montreal Cognitive Assessment (MoCA). The computerized battery of the Central Nervous System Vital Signs (CNS VS) test was used to diagnose cognitive functions. APOE genotyping was performed by multiplex PCR. The blood plasma CRP levels were determined. Statistical analysis was performed using Statistica software.

Results: The level of neurocognitive index (NCI) and cognitive functions in post-menopausal women depends on apolipoprotein E gene polymorphism ( < 0.001) and the concentration of CRP ( < 0.05). A negative correlation was found between CRP and NCI ( = 0.018), and the reaction time ( = 0.008) of women with APOE ε2/ε3. A positive correlation was observed between CRP and visual memory ( = 0.025) in women with APOE ε3/ε3, and verbal memory ( = 0.023) in women with APOE ε3/ε4 or ε4/ε4.

Conclusions: Apolipoprotein E gene polymorphism may modify the relationship between CRP concentration and cognitive functions in post-menopausal women.

Citing Articles

Effect of interactions between and polymorphisms on cognitive functions in postmenopausal women.

Pinkas J, Bojar I, Gujski M, Sarecka-Hujar B, Owoc A, Raczkiewicz D Arch Med Sci. 2021; 17(1):31-39.

PMID: 33488853 PMC: 7811303. DOI: 10.5114/aoms.2018.72972.

APOE - a genetic marker of comorbidity in subjects with morbid obesity.

Farup P, Rootwelt H, Hestad K BMC Med Genet. 2020; 21(1):146.

PMID: 32646381 PMC: 7346600. DOI: 10.1186/s12881-020-01082-2.

Apolipoprotein E genotype and the association between C-reactive protein and postoperative delirium: Importance of gene-protein interactions.

Vasunilashorn S, Ngo L, Inouye S, Fong T, Jones R, Dillon S Alzheimers Dement. 2019; 16(3):572-580.

PMID: 31761478 PMC: 7086383. DOI: 10.1016/j.jalz.2019.09.080.

The many menopauses: searching the cognitive research literature for menopause types.

Edwards H, Duchesne A, Au A, Einstein G Menopause. 2018; 26(1):45-65.

PMID: 29994973 PMC: 6314513. DOI: 10.1097/GME.0000000000001171.

References

Stephan B, Brayne C, McKeith I, Bond J, Matthews F . Mild cognitive impairment in the older population: Who is missed and does it matter?. Int J Geriatr Psychiatry. 2008; 23(8):863-71. DOI: 10.1002/gps.2013. View

Yue Y, Ling Hu , Tian Q, Jiang J, Dong Y, Jin Z . Effects of long-term, low-dose sex hormone replacement therapy on hippocampus and cognition of postmenopausal women of different apoE genotypes. Acta Pharmacol Sin. 2007; 28(8):1129-35. DOI: 10.1111/j.1745-7254.2007.00618.x. View

Birkenhager W, Forette F, Seux M, Wang J, Staessen J . Blood pressure, cognitive functions, and prevention of dementias in older patients with hypertension. Arch Intern Med. 2001; 161(2):152-6. DOI: 10.1001/archinte.161.2.152. View

Blasko I, Knaus G, Weiss E, Kemmler G, Winkler C, Falkensammer G . Cognitive deterioration in Alzheimer's disease is accompanied by increase of plasma neopterin. J Psychiatr Res. 2006; 41(8):694-701. DOI: 10.1016/j.jpsychires.2006.02.001. View

Yang Y, Kim J, Park S, Kim S, Jeon O, Kim D . Apolipoprotein E genotyping by multiplex tetra-primer amplification refractory mutation system PCR in single reaction tube. J Biotechnol. 2007; 131(2):106-10. DOI: 10.1016/j.jbiotec.2007.06.001. View

Haan M, Aiello A, West N, Jagust W . C-reactive protein and rate of dementia in carriers and non carriers of Apolipoprotein APOE4 genotype. Neurobiol Aging. 2007; 29(12):1774-82. PMC: 2593150. DOI: 10.1016/j.neurobiolaging.2007.04.020. View

Ge X, Xu X, Feng C, Wang Y, Li Y, Feng B . Relationships among serum C-reactive protein, receptor for advanced glycation products, metabolic dysfunction, and cognitive impairments. BMC Neurol. 2013; 13:110. PMC: 3765839. DOI: 10.1186/1471-2377-13-110. View

Wroolie T, Kenna H, Williams K, Powers B, Holcomb M, Lazzeroni L . Cognitive effects of memantine in postmenopausal women at risk of dementia: a pilot study. Acta Neurol Scand. 2008; 119(3):172-9. DOI: 10.1111/j.1600-0404.2008.01084.x. View

Gromadzka G, Baranska-Gieruszczak M, Sarzynska-Dlugosz I, Ciesielska A, Czlonkowska A . The APOE polymorphism and 1-year outcome in ischemic stroke: genotype-gender interaction. Acta Neurol Scand. 2007; 116(6):392-8. DOI: 10.1111/j.1600-0404.2007.00880.x. View

10.

Roberts R, Geda Y, Knopman D, Boeve B, Christianson T, Pankratz V . Association of C-reactive protein with mild cognitive impairment. Alzheimers Dement. 2009; 5(5):398-405. PMC: 2851170. DOI: 10.1016/j.jalz.2009.01.025. View

11.

Yen M, Yang C, Linju Yen B, Ho Y, Cheng W, Bai C . Increased high sensitivity C-reactive protein and neutrophil count are related to increased standard cardiovascular risk factors in healthy Chinese men. Int J Cardiol. 2005; 110(2):191-8. DOI: 10.1016/j.ijcard.2005.07.034. View

12.

Mitchell A, Shiri-Feshki M . Rate of progression of mild cognitive impairment to dementia--meta-analysis of 41 robust inception cohort studies. Acta Psychiatr Scand. 2009; 119(4):252-65. DOI: 10.1111/j.1600-0447.2008.01326.x. View

13.

Elias-Sonnenschein L, Viechtbauer W, Ramakers I, Verhey F, Visser P . Predictive value of APOE-ε4 allele for progression from MCI to AD-type dementia: a meta-analysis. J Neurol Neurosurg Psychiatry. 2011; 82(10):1149-56. DOI: 10.1136/jnnp.2010.231555. View

14.

Tilvis R, Kahonen-Vare M, Jolkkonen J, Valvanne J, Pitkala K, Strandberg T . Predictors of cognitive decline and mortality of aged people over a 10-year period. J Gerontol A Biol Sci Med Sci. 2004; 59(3):268-74. DOI: 10.1093/gerona/59.3.m268. View

15.

Liu Y, Yu J, Wang H, Han P, Tan C, Wang C . APOE genotype and neuroimaging markers of Alzheimer's disease: systematic review and meta-analysis. J Neurol Neurosurg Psychiatry. 2014; 86(2):127-34. PMC: 4331076. DOI: 10.1136/jnnp-2014-307719. View

16.

Lima T, Adler A, Minett T, Matthews F, Brayne C, Marioni R . C-reactive protein, APOE genotype and longitudinal cognitive change in an older population. Age Ageing. 2013; 43(2):289-92. PMC: 3927773. DOI: 10.1093/ageing/aft193. View

17.

Weber M, Mapstone M . Memory complaints and memory performance in the menopausal transition. Menopause. 2009; 16(4):694-700. DOI: 10.1097/gme.0b013e318196a0c9. View

18.

Yaffe K, Kanaya A, Lindquist K, Simonsick E, Harris T, Shorr R . The metabolic syndrome, inflammation, and risk of cognitive decline. JAMA. 2004; 292(18):2237-42. DOI: 10.1001/jama.292.18.2237. View

19.

Zolnierczuk-Kieliszek D, Kulik T, Jarosz M, Stefanowicz A, Pacian A, Pacian J . Quality of life in peri- and post-menopausal Polish women living in Lublin Province--differences between urban and rural dwellers. Ann Agric Environ Med. 2012; 19(1):129-33. View

20.

Bojar I, Wojcik-Fatla A, Owoc A, Lewinski A . Polymorphisms of apolipoprotein E gene and cognitive functions of postmenopausal women, measured by battery of computer tests - Central Nervous System Vital Signs. Neuro Endocrinol Lett. 2012; 33(4):385-92. View