APRIL, BCMA and TACI Proteins Are Abnormally Expressed in Non-small Cell Lung Cancer

Overview

Journal Oncol Lett

Specialty Oncology

Date 2016 Dec 1

PMID 27900003

Citations 7

Authors

Hengli Dou

Zhaohua Yan

Meng Zhang

Xiaoxin Xu

Affiliations

Soon will be listed here.

Abstract

Lung cancer is the leading cause of cancer-associated mortality. Non-small cell lung cancer (NSCLC) accounts for >80% of lung cancers. The overall survival for NSCLC is dismal, with a 5-year survival of <5% for patients. Thus, identifying an effective biomarker for early diagnosis of lung cancer is the first essential step to reduce mortality. It has been recognized that certain inflammatory and immune responses are important in lung cancer development and prevention. The present study demonstrated that, in NSCLC, a proliferation-inducing ligand (APRIL), B-cell maturation antigen (BCMA)and transmembrane activator and CAML interactor (TACI) proteins are abnormally expressed by immunohistochemistry, reverse transcription-quantitative polymerase chain reaction and western blotting. In addition, the expression of APRIL, BCMA and TACI were observed to be involved in extracellular signal-regulated kinase (ERK)1/2 activation in A549 cells. Overall, the present study provides evidence that APRIL and its receptors, BCMA and TACI, may play roles in the biological processes of NSCLC tumors through the ERK1/2 signaling pathway.

Citing Articles

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The effects of BAFF and APRIL signaling on non-small cell lung cancer cell proliferation and invasiveness.

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Prognostic Significance of Serum BAFF, APRIL, TACI and BCMA Levels in Chronic Lymphocytic Leukemia.

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