Human (HLA-A and HLA-B) and Murine (H-2K and H-2D) Histocompatibility Antigens Are Cell Surface Receptors for Semliki Forest Virus

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 1978 Aug 1

PMID 278998

Citations 63

Authors

A Helenius

B Morein

E Fries

K Simons

P Robinson

V Schirrmacher

C Terhorst

J L Strominger

Affiliations

Soon will be listed here.

Abstract

The proteins coded for by the HLA-A and HLA-B loci in man and the H-2K and H-2D loci in mice were identified as cell surface receptors for Semliki Forest virus. This conclusion is based on the following observations: (i) Water-soluble octamers of viral coat proteins inhibit the complement-dependent cytotoxicity of antibodies directed against H-2K and H-2D antigens in mouse cells. (ii) Isolated detergent-soluble HLA-A and HLA-B antigens reconstituted in lipid vesicles inhibit the binding of viral proteins to human cells (as do the water-soluble antigens to a lesser extent). (iii) Reconstituted HLA-A and HLA-B vesicles interact in solution with Semliki Forest virus (or with vesicles containing viral spike proteins), as demonstrated by coprecipitation with antisera. (iv) Complexes between viral spoke proteins and HLA-A and HLA-B antigens or H-2K and H-2D antigens can be isolated from the cell surface by utilizing affinity chromatography or immunoprecipitation.

Citing Articles

A molecular understanding of alphavirus entry and antibody protection.

Kim A, Diamond M Nat Rev Microbiol. 2022; 21(6):396-407.

PMID: 36474012 PMC: 9734810. DOI: 10.1038/s41579-022-00825-7.

Comparative Characterization of the Sindbis Virus Proteome from Mammalian and Invertebrate Hosts Identifies nsP2 as a Component of the Virion and Sorting Nexin 5 as a Significant Host Factor for Alphavirus Replication.

Schuchman R, Kilianski A, Piper A, Vancini R, Ribeiro J, Sprague T J Virol. 2018; 92(14).

PMID: 29743363 PMC: 6026752. DOI: 10.1128/JVI.00694-18.

Oncolytic Alphaviruses in Cancer Immunotherapy.

Lundstrom K Vaccines (Basel). 2017; 5(2).

PMID: 28417936 PMC: 5492006. DOI: 10.3390/vaccines5020009.

Influenza A virus hemagglutinin and neuraminidase act as novel motile machinery.

Sakai T, Nishimura S, Naito T, Saito M Sci Rep. 2017; 7:45043.

PMID: 28344335 PMC: 5366856. DOI: 10.1038/srep45043.

Comparative protein profiling of B16 mouse melanoma cells susceptible and non-susceptible to alphavirus infection: Effect of the tumor microenvironment.

Vasilevska J, Antonio de Souza G, Stensland M, Skrastina D, Zhulenvovs D, Paplausks R Cancer Biol Ther. 2016; 17(10):1035-1050.

PMID: 27636533 PMC: 5079404. DOI: 10.1080/15384047.2016.1219813.

References

Wigzell H . QUANTITATIVE TITRATIONS OF MOUSE H-2 ANTIBODIES USING CR-51-LABELLED TARGET CELLS. Transplantation. 1965; 3:423-31. DOI: 10.1097/00007890-196505000-00011. View

Ostberg L, Rask L, Nilsson K, Peterson P . Independent expression of the two HL-A antigen polypeptide chains. Eur J Immunol. 1976; 5(7):462-8. DOI: 10.1002/eji.1830050707. View

Yefenof E, Klein G, Kvarnung K . Relationships between complement activation, complement binding, and EBV absorption by human hematopoietic cell lines. Cell Immunol. 1977; 31(2):225-33. DOI: 10.1016/0008-8749(77)90024-7. View

Kessler S . Cell membrane antigen isolation with the staphylococcal protein A-antibody adsorbent. J Immunol. 1976; 117(5 Pt 1):1482-90. View

Engelhard V, Guild B, Helenius A, Terhorst C, Strominger J . Reconstitution of purified detergent-soluble HLA-A and HLA-B antigens into phospholipid vesicles. Proc Natl Acad Sci U S A. 1978; 75(7):3230-4. PMC: 392748. DOI: 10.1073/pnas.75.7.3230. View

Hennache B, BOULANGER P . Biochemical study of KB-cell receptor for adenovirus. Biochem J. 1977; 166(2):237-47. PMC: 1165000. DOI: 10.1042/bj1660237. View

Helenius A, Fries E, Kartenbeck J . Reconstitution of Semliki forest virus membrane. J Cell Biol. 1977; 75(3):866-80. PMC: 2111584. DOI: 10.1083/jcb.75.3.866. View

Hilfenhaus J . Propagation of Semliki Forest virus in various human lymphoblastoid cell lines. J Gen Virol. 1976; 33(3):539-42. DOI: 10.1099/0022-1317-33-3-539. View

Haywood A . Characteristics of Sendai virus receptors in a model membrane. J Mol Biol. 1974; 83(4):427-36. DOI: 10.1016/0022-2836(74)90504-x. View

10.

Nilsson K, Evrin P, Welsh K . Production of beta 2-microglobulin by normal and malignant human cell lines and peripheral lymphocytes. Transplant Rev. 1974; 21(0):53-84. DOI: 10.1111/j.1600-065x.1974.tb01546.x. View

11.

Strominger J, Cresswell P, Grey H, Humphreys R, Mann D, McCuneJ . The immunoglobulin-like structure of human histocompatibility antigens. Transplant Rev. 1974; 21(0):126-43. DOI: 10.1111/j.1600-065x.1974.tb01549.x. View

12.

Sanderson A, Welsh K . Properties of histocompatibility (HL-A) determinants. I. Site density of antigens of the two HL-A segregant series on peripheral human lymphocytes. Transplantation. 1974; 17(3):281-9. View

13.

Neauport-Sautes C, Bismuth A, KOURILSKY F, MANUEL Y . Relationship between HL-A antigens and beta-2-microglobulin as studied by immunofluorescence on the lymphocyte membrane. J Exp Med. 1974; 139(4):957-68. PMC: 2139575. DOI: 10.1084/jem.139.4.957. View

14.

Mooney J, Dalrymple J, Alving C, RUSSELL P . Interaction of Sindbis virus with liposomal model membranes. J Virol. 1975; 15(2):225-31. PMC: 354443. DOI: 10.1128/JVI.15.2.225-231.1975. View

15.

Dales S . Early events in cell-animal virus interactions. Bacteriol Rev. 1973; 37(2):103-35. PMC: 413808. DOI: 10.1128/br.37.2.103-135.1973. View

16.

Robb R, Strominger J . Rapid purification of detergent-solubilized HLA antigen by affinity chromatography employing anti-beta2-microglobulin serum. J Biol Chem. 1976; 251(17):5427-8. View

17.

Utermann G, Simons K . Studies on the amphipathic nature of the membrane proteins in Semliki Forest virus. J Mol Biol. 1974; 85(4):569-87. DOI: 10.1016/0022-2836(74)90316-7. View

18.

McCune J, Humphreys R, Yocum R, Strominger J . Enhanced representation of HL-A antigens on human lymphocytes after mitogenesis induced by phytohemagglutinin or Epstein-Barr virus. Proc Natl Acad Sci U S A. 1975; 72(8):3206-9. PMC: 432951. DOI: 10.1073/pnas.72.8.3206. View

19.

Birdwell C, Strauss J . Distribution of the receptor sites for Sindbis virus on the surface of chicken and BHK cells. J Virol. 1974; 14(3):672-8. PMC: 355562. DOI: 10.1128/JVI.14.3.672-678.1974. View

20.

Simons K, Helenius A, Garoff H . Solubilization of the membrane proteins from Semliki Forest virus with Triton X100. J Mol Biol. 1973; 80(1):119-33. DOI: 10.1016/0022-2836(73)90236-2. View