High Vitamin D Consumption Is Inversely Associated with Cardiovascular Disease Risk in an Urban Mexican Population

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2016 Nov 29

PMID 27893863

Citations 3

Authors

Paloma Munoz-Aguirre

Edgar Denova-Gutierrez

Mario Flores

Eduardo Salazar-Martinez

Jorge Salmeron

Affiliations

Soon will be listed here.

Abstract

Background: Vitamin D deficiency is a major global public health problem. Recent epidemiological studies have assessed the relationship between vitamin D and multiple outcomes, including cardiovascular disease. However, this evidence is limited and inconclusive. Our purpose in this study was to evaluate the association between dietary vitamin D intake and cardiovascular disease risk in adult Mexican population.

Methods: We conducted a cross-sectional analysis with the baseline data from 6294 men and women aged 20-80 years participating in the Health Workers Cohort Study. Data on sociodemographic, lifestyle, and medical history factors were collected with a self-administered questionnaire. Dietary intake was evaluated by using a semi-quantitative food-frequency questionnaire. Cardiovascular disease risk was calculated using a recalibration of the Framingham heart disease prediction score. To evaluate the association between vitamin D intake and 10-year cardiovascular disease risk, odds ratios (OR) and 95% confidence intervals (95% CI) were calculated using multiple logistic regression analysis.

Results: A total of 6294 subjects (1820 men and 4474 women) with a mean age of 42 years, were included. Of these, subjects in the highest quintile of vitamin D intake presented lower levels of triglycerides 14.6 mg/dL (P for trend = 0.001); 2.0 cm less in waist circumference (P for trend = 0.001) and 0.8 points less in the Framingham cardiovascular disease risk score (P for trend = 0.002) compared with the subjects in the lower quintile of vitamin D intake. Additionally, participants in the highest quintile of vitamin D consumption were less likely to develop elevated 10-year cardiovascular disease risk, compared with those in the lowest quintile (OR = 0.51; 95%CI: 0.33, 0.77; P for trend = 0.007).

Conclusion: Our data suggest that higher consumption of vitamin D is associated with a reduced risk of cardiovascular disease in Mexican population.

Citing Articles

Association between serum 25-hydroxyvitamin D concentrations and metabolic syndrome in the middle-aged and elderly Chinese population in Dalian, northeast China: A cross-sectional study.

Weldegiorgis T, Hidru T, Yang X, Xia Y, Ma L, Li H J Diabetes Investig. 2019; 11(1):184-191.

PMID: 31145541 PMC: 6944851. DOI: 10.1111/jdi.13086.

Cardiovascular Risk Factors and Their Association with Vitamin D Deficiency in Mexican Women of Reproductive Age.

Contreras-Manzano A, Villalpando S, Garcia-Diaz C, Flores-Aldana M Nutrients. 2019; 11(6).

PMID: 31141980 PMC: 6627884. DOI: 10.3390/nu11061211.

Differences in the relation between bone mineral content and lean body mass according to gender and reproductive status by age ranges.

Denova-Gutierrez E, Clark P, Capozza R, Nocciolino L, Ferretti J, Velazquez-Cruz R J Bone Miner Metab. 2018; 37(4):749-758.

PMID: 30515578 DOI: 10.1007/s00774-018-0978-0.

References

Holick M . Vitamin D deficiency. N Engl J Med. 2007; 357(3):266-81. DOI: 10.1056/NEJMra070553. View

Zittermann A, Frisch S, Berthold H, Gotting C, Kuhn J, Kleesiek K . Vitamin D supplementation enhances the beneficial effects of weight loss on cardiovascular disease risk markers. Am J Clin Nutr. 2009; 89(5):1321-7. DOI: 10.3945/ajcn.2008.27004. View

Parker J, Hashmi O, Dutton D, Mavrodaris A, Stranges S, Kandala N . Levels of vitamin D and cardiometabolic disorders: systematic review and meta-analysis. Maturitas. 2009; 65(3):225-36. DOI: 10.1016/j.maturitas.2009.12.013. View

Sun Q, Shi L, Rimm E, Giovannucci E, Hu F, Manson J . Vitamin D intake and risk of cardiovascular disease in US men and women. Am J Clin Nutr. 2011; 94(2):534-42. PMC: 3142728. DOI: 10.3945/ajcn.110.008763. View

Looker A, Pfeiffer C, Lacher D, Schleicher R, Picciano M, Yetley E . Serum 25-hydroxyvitamin D status of the US population: 1988-1994 compared with 2000-2004. Am J Clin Nutr. 2008; 88(6):1519-27. PMC: 2745830. DOI: 10.3945/ajcn.2008.26182. View

DAgostino Sr R, Grundy S, Sullivan L, Wilson P . Validation of the Framingham coronary heart disease prediction scores: results of a multiple ethnic groups investigation. JAMA. 2001; 286(2):180-7. DOI: 10.1001/jama.286.2.180. View

Watson K, Abrolat M, Malone L, Hoeg J, Doherty T, Detrano R . Active serum vitamin D levels are inversely correlated with coronary calcification. Circulation. 1997; 96(6):1755-60. DOI: 10.1161/01.cir.96.6.1755. View

Li Y, Qiao G, Uskokovic M, Xiang W, Zheng W, Kong J . Vitamin D: a negative endocrine regulator of the renin-angiotensin system and blood pressure. J Steroid Biochem Mol Biol. 2004; 89-90(1-5):387-92. DOI: 10.1016/j.jsbmb.2004.03.004. View

Borges A, Feres T, Vianna L, Paiva T . Recovery of impaired K+ channels in mesenteric arteries from spontaneously hypertensive rats by prolonged treatment with cholecalciferol. Br J Pharmacol. 1999; 127(3):772-8. PMC: 1566052. DOI: 10.1038/sj.bjp.0702581. View

10.

Ohsawa M, Koyama T, Yamamoto K, Hirosawa S, Kamei S, Kamiyama R . 1alpha,25-dihydroxyvitamin D(3) and its potent synthetic analogs downregulate tissue factor and upregulate thrombomodulin expression in monocytic cells, counteracting the effects of tumor necrosis factor and oxidized LDL. Circulation. 2000; 102(23):2867-72. DOI: 10.1161/01.cir.102.23.2867. View

11.

Borges A, Feres T, Vianna L, Paiva T . Effect of cholecalciferol treatment on the relaxant responses of spontaneously hypertensive rat arteries to acetylcholine. Hypertension. 1999; 34(4 Pt 2):897-901. DOI: 10.1161/01.hyp.34.4.897. View

12.

Munoz-Aguirre P, Flores M, Macias N, Quezada A, Denova-Gutierrez E, Salmeron J . The effect of vitamin D supplementation on serum lipids in postmenopausal women with diabetes: A randomized controlled trial. Clin Nutr. 2014; 34(5):799-804. DOI: 10.1016/j.clnu.2014.10.002. View

13.

Jorde R, Grimnes G . Vitamin D and metabolic health with special reference to the effect of vitamin D on serum lipids. Prog Lipid Res. 2011; 50(4):303-12. DOI: 10.1016/j.plipres.2011.05.001. View

14.

OConnell T, Berry J, Jarvis A, Somerman M, Simpson R . 1,25-Dihydroxyvitamin D3 regulation of cardiac myocyte proliferation and hypertrophy. Am J Physiol. 1997; 272(4 Pt 2):H1751-8. DOI: 10.1152/ajpheart.1997.272.4.H1751. View

15.

Lu L, Yu Z, Pan A, Hu F, Franco O, Li H . Plasma 25-hydroxyvitamin D concentration and metabolic syndrome among middle-aged and elderly Chinese individuals. Diabetes Care. 2009; 32(7):1278-83. PMC: 2699709. DOI: 10.2337/dc09-0209. View

16.

Denova-Gutierrez E, Castanon S, Talavera J, Flores M, Macias N, Rodriguez-Ramirez S . Dietary patterns are associated with different indexes of adiposity and obesity in an urban Mexican population. J Nutr. 2011; 141(5):921-7. DOI: 10.3945/jn.110.132332. View

17.

Kayaniyil S, Vieth R, Harris S, Retnakaran R, Knight J, Gerstein H . Association of 25(OH)D and PTH with metabolic syndrome and its traditional and nontraditional components. J Clin Endocrinol Metab. 2010; 96(1):168-75. DOI: 10.1210/jc.2010-1439. View

18.

Denova-Gutierrez E, Huitron-Bravo G, Talavera J, Castanon S, Gallegos-Carrillo K, Flores Y . Dietary glycemic index, dietary glycemic load, blood lipids, and coronary heart disease. J Nutr Metab. 2010; 2010. PMC: 2911609. DOI: 10.1155/2010/170680. View

19.

Denova-Gutierrez E, Talavera J, Huitron-Bravo G, Mendez-Hernandez P, Salmeron J . Sweetened beverage consumption and increased risk of metabolic syndrome in Mexican adults. Public Health Nutr. 2010; 13(6):835-42. DOI: 10.1017/S1368980009991145. View

20.

Denova-Gutierrez E, Castanon S, Talavera J, Gallegos-Carrillo K, Flores M, Dosamantes-Carrasco D . Dietary patterns are associated with metabolic syndrome in an urban Mexican population. J Nutr. 2010; 140(10):1855-63. DOI: 10.3945/jn.110.122671. View