Female Gender Lost Protective Effect Against Disease Progression in Elderly Patients with Chronic Hepatitis B

Overview

Journal Sci Rep

Specialty Science

Date 2016 Nov 29

PMID 27892487

Citations 8

Authors

Hong You

Yuanyuan Kong

Jinlin Hou

Lai Wei

Yuexin Zhang

Junqi Niu

Tao Han

Xiaojuan Ou

Xiaoguang Dou

Jia Shang

Hong Tang

Qing Xie

Huiguo Ding

Hong Ren

Xiaoyuan Xu

Wen Xie

Xiaoqing Liu

Youqing Xu

Yujie Li

Jie Li

Shein-Chung Chow

Hui Zhuang

Jidong Jia

Affiliations

Soon will be listed here.

Abstract

Female gender and younger age are protective factors against disease progression in chronic hepatitis B (CHB). However, it is not clear whether the disease progression still remains slow in elderly females. This study investigated the interaction of female gender and older age on the development of cirrhosis in patients recorded in China Registry of Hepatitis B. A total of 17,809 CHB patients were enrolled in this multi-center cross-sectional study. The prevalence of cirrhosis in female CHB patients increased faster than that in male CHB patients over 50 years old. Multivariate analysis showed that the increase of adjusted ORs for developing cirrhosis in females started to accelerate after 50 years old: 11.19 (95% CI: 5.93-21.11) in women versus 14.75 (95% CI: 8.35-26.07) in men at ages of 50-59 years, 21.67 (95% CI: 11.05-42.47) versus 24.4 (95% CI: 13.00-45.80) at ages 60-69 years, and 18.78 (95% CI: 6.61-53.36) versus 12.09 (95% CI: 4.35-33.61) in those over 70 years. In conclusion, the protective effect of female gender against cirrhosis gradually lost with increasing age, therefore disease progression should be monitored more closely in elderly women with CHB.

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