Diacylglycerol Kinases in T Cell Tolerance and Effector Function

Overview

Journal Front Cell Dev Biol

Specialty Cell Biology

Date 2016 Nov 29

PMID 27891502

Citations 17

Authors

Shelley S Chen

Zhiming Hu

Xiao-Ping Zhong

Affiliations

Soon will be listed here.

Abstract

Diacylglycerol kinases (DGKs) are a family of enzymes that regulate the relative levels of diacylglycerol (DAG) and phosphatidic acid (PA) in cells by phosphorylating DAG to produce PA. Both DAG and PA are important second messengers cascading T cell receptor (TCR) signal by recruiting multiple effector molecules, such as RasGRP1, PKCθ, and mTOR. Studies have revealed important physiological functions of DGKs in the regulation of receptor signaling and the development and activation of immune cells. In this review, we will focus on recent progresses in our understanding of two DGK isoforms, α and ζ, in CD8 T effector and memory cell differentiation, regulatory T cell development and function, and invariant NKT cell development and effector lineage differentiation.

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