Serotonin Receptor Binding Affinities of Several Hallucinogenic Phenylalkylamine and N,N-dimethyltryptamine Analogues

Overview

Journal J Med Chem

Publisher American Chemical Society

Specialty Chemistry

Date 1978 Aug 1

PMID 278843

Citations 8

Authors

R A Glennon

S M Liebowitz

E C Mack

Affiliations

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Abstract

Hallucinogenic phenylalkylamine and N,N-dimethyltryptamine analogues are known to affect serotonergic systems both in vivo and in vitro. Using a rat stomach fundus model, the 5-HT receptor binding affinities of several of these analogues were determined and compared. The most behaviorally potent analogues examined, DOB, DOM, and 5-methoxy-N,N-dimethyltryptamine, were found to possess rather high affirmities (pA2 = 7.35, 7.12, and 7.08, respectively) for the 5-HT receptors of the model system.

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