Evaluation of Interferon-induced Transmembrane Protein-3 () Rs7478728 and Rs3888188 Polymorphisms and the Risk of Pulmonary Tuberculosis

Overview

Journal Biomed Rep

Specialty Biochemistry

Date 2016 Nov 25

PMID 27882230

Citations 3

Authors

Mohammad Naderi

Mohammad Hashemi

Fatemeh Abedipour

Gholamreza Bahari

Maryam Rezaei

Mohsen Taheri

Affiliations

Soon will be listed here.

Abstract

The current study aimed to examine the possible association between the interferon-induced transmembrane protein-3 () gene polymorphisms and risk of pulmonary tuberculosis (PTB) in a sample population. This case-control study was conducted on 188 PTB patients and 169 healthy subjects. The rs7478728 and rs3888188 variants of were genotyped using polymerase chain reaction-restriction fragment length polymorphism. The findings showed no significant association between rs7478728 polymorphism and risk of PTB. Regarding rs3888188 polymorphism, the TG genotype as well as G allele significantly increased the risk of PTB [odds ratio (OR)=2.48, 95% confidence interval (CI): 1.42-4.53; P=0.002, and OR=2.26, 95% CI: 1.33-3.86; P=0.003, respectively]. In conclusion, the findings revealed that rs3888188 polymorphism increased the risk of PTB in a sample of Iranian population. Additional investigation with larger sample sizes and different ethnicities are needed to verify our findings.

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