Phomopsichin A-D; Four New Chromone Derivatives from Mangrove Endophytic Fungus Phomopsis Sp. 33

Overview

Journal Mar Drugs

Publisher MDPI

Specialties Biology
Pharmacology

Date 2016 Nov 24

PMID 27879655

Citations 8

Authors

Meixiang Huang

Jing Li

Lan Liu

Sheng Yin

Jun Wang

Yongcheng Lin

Affiliations

Soon will be listed here.

Abstract

Four new chromone derivatives, phomopsichins A-D (-), along with a known compound, phomoxanthone A (), were isolated from the fermentation products of mangrove endophytic fungus sp. 33#. Their structures were elucidated based on comprehensive spectroscopic analysis coupled with single-crystal X-ray diffraction or theoretical calculations of electronic circular dichroism (ECD). They feature a tricyclic framework, in which a dihydropyran ring is fused with the chromone ring. Compounds - showed weak inhibitory activities on acetylcholinesterase as well as α-glucosidase, weak radical scavenging effects on 1,1-diphenyl-2-picrylhydrazyl (DPPH) as well as OH, and weak antimicrobial activities. Compounds - showed no cytotoxic activity against MDA-MB-435 breast cancer cells. Their other bioactivities are worthy of further study, considering their unique molecular structures.

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