Biopolymeric Nanoparticles

Overview

Journal Sci Technol Adv Mater

Specialty Biomedical Engineering

Date 2016 Nov 24

PMID 27877319

Citations 58

Authors

Sushmitha Sundar

Joydip Kundu

Subhas C Kundu

Affiliations

Soon will be listed here.

Abstract

This review on nanoparticles highlights the various biopolymers (proteins and polysaccharides) which have recently revolutionized the world of biocompatible and degradable natural biological materials. The methods of their fabrication, including emulsification, desolvation, coacervation and electrospray drying are described. The characterization of different parameters for a given nanoparticle, such as particle size, surface charge, morphology, stability, structure, cellular uptake, cytotoxicity, drug loading and drug release, is outlined together with the relevant measurement techniques. Applications in the fields of medicine and biotechnology are discussed along with a promising future scope.

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References

Kundu J, Chung Y, Kim Y, Tae G, Kundu S . Silk fibroin nanoparticles for cellular uptake and control release. Int J Pharm. 2010; 388(1-2):242-50. DOI: 10.1016/j.ijpharm.2009.12.052. View

Mladenovska K, Cruaud O, Richomme P, Belamie E, Raicki R, Venier-Julienne M . 5-ASA loaded chitosan-Ca-alginate microparticles: Preparation and physicochemical characterization. Int J Pharm. 2007; 345(1-2):59-69. DOI: 10.1016/j.ijpharm.2007.05.059. View

Vauthier C, Dubernet C, Chauvierre C, Brigger I, Couvreur P . Drug delivery to resistant tumors: the potential of poly(alkyl cyanoacrylate) nanoparticles. J Control Release. 2003; 93(2):151-60. DOI: 10.1016/j.jconrel.2003.08.005. View

Scheffel U, Rhodes B, Natarajan T, Wagner Jr H . Albumin microspheres for study of the reticuloendothelial system. J Nucl Med. 1972; 13(7):498-503. View

Dash R, Mandal M, Ghosh S, Kundu S . Silk sericin protein of tropical tasar silkworm inhibits UVB-induced apoptosis in human skin keratinocytes. Mol Cell Biochem. 2008; 311(1-2):111-9. DOI: 10.1007/s11010-008-9702-z. View

Altman G, Diaz F, Jakuba C, Calabro T, Horan R, Chen J . Silk-based biomaterials. Biomaterials. 2002; 24(3):401-16. DOI: 10.1016/s0142-9612(02)00353-8. View

Florence A . The oral absorption of micro- and nanoparticulates: neither exceptional nor unusual. Pharm Res. 1997; 14(3):259-66. DOI: 10.1023/a:1012029517394. View

Aramwit P, Kanokpanont S, De-Eknamkul W, Kamei K, Srichana T . The effect of sericin with variable amino-acid content from different silk strains on the production of collagen and nitric oxide. J Biomater Sci Polym Ed. 2009; 20(9):1295-306. DOI: 10.1163/156856209X453006. View

Betancor L, Luckarift H . Bioinspired enzyme encapsulation for biocatalysis. Trends Biotechnol. 2008; 26(10):566-72. DOI: 10.1016/j.tibtech.2008.06.009. View

10.

Kawashima Y, Handa T, Kasai A, Takenaka H, Lin S, Ando Y . Novel method for the preparation of controlled-release theophylline granules coated with a polyelectrolyte complex of sodium polyphosphate-chitosan. J Pharm Sci. 1985; 74(3):264-8. DOI: 10.1002/jps.2600740308. View

11.

Nakagawa Y, Takayama K, Ueda H, Machida Y, Nagai T . Preparation of bovine serum albumin nanospheres as drug targeting carriers. Drug Des Deliv. 1987; 2(2):99-107. View

12.

Vila A, Sanchez A, Janes K, Behrens I, Kissel T, Vila Jato J . Low molecular weight chitosan nanoparticles as new carriers for nasal vaccine delivery in mice. Eur J Pharm Biopharm. 2004; 57(1):123-31. DOI: 10.1016/j.ejpb.2003.09.006. View

13.

Langer K, Balthasar S, Vogel V, Dinauer N, von Briesen H, Schubert D . Optimization of the preparation process for human serum albumin (HSA) nanoparticles. Int J Pharm. 2003; 257(1-2):169-80. DOI: 10.1016/s0378-5173(03)00134-0. View

14.

Gao Z, Shukla A, Johnson J, Crowley W . Controlled release of a contraceptive steroid from biodegradable and injectable gel formulations: in vitro evaluation. Pharm Res. 1995; 12(6):857-63. DOI: 10.1023/a:1016209020160. View

15.

Kommareddy S, Amiji M . Preparation and evaluation of thiol-modified gelatin nanoparticles for intracellular DNA delivery in response to glutathione. Bioconjug Chem. 2005; 16(6):1423-32. DOI: 10.1021/bc050146t. View

16.

Illum L, Farraj N, Davis S . Chitosan as a novel nasal delivery system for peptide drugs. Pharm Res. 1994; 11(8):1186-9. DOI: 10.1023/a:1018901302450. View

17.

Pan W . Preparation and distribution of 5-fluorouracil (125)I sodium alginate-bovine serum albumin nanoparticles. World J Gastroenterol. 2002; 5(1):57-60. PMC: 4688503. DOI: 10.3748/wjg.v5.i1.57. View

18.

Emile C, Bazile D, Herman F, Helene C, Veillard M . Encapsulation of oligonucleotides in stealth Me.PEG-PLA50 nanoparticles by complexation with structured oligopeptides. Drug Deliv. 2016; 3(3):187-95. DOI: 10.3109/10717549609029449. View

19.

Rajaonarivony M, Vauthier C, Couarraze G, Puisieux F, Couvreur P . Development of a new drug carrier made from alginate. J Pharm Sci. 1993; 82(9):912-7. DOI: 10.1002/jps.2600820909. View

20.

Merodio M, Irache J, Eclancher F, Mirshahi M, Villarroya H . Distribution of albumin nanoparticles in animals induced with the experimental allergic encephalomyelitis. J Drug Target. 2001; 8(5):289-303. DOI: 10.3109/10611860008997907. View