Natural Products As Mediators of Disease

Overview

Journal Nat Prod Rep

Publisher Royal Society of Chemistry

Date 2016 Nov 23

PMID 27874907

Citations 24

Authors

Neha Garg

Tal Luzzatto-Knaan

Alexey V Melnik

Andres Mauricio Caraballo-Rodriguez

Dimitrios J Floros

Daniel Petras

Rachel Gregor

Pieter C Dorrestein

Vanessa V Phelan

Affiliations

Soon will be listed here.

Abstract

Covering: up to 2016Humans are walking microbial ecosystems, each harboring a complex microbiome with the genetic potential to produce a vast array of natural products. Recent sequencing data suggest that our microbial inhabitants are critical for maintaining overall health. Shifts in microbial communities have been correlated to a number of diseases including infections, inflammation, cancer, and neurological disorders. Some of these clinically and diagnostically relevant phenotypes are a result of the presence of small molecules, yet we know remarkably little about their contributions to the health of individuals. Here, we review microbe-derived natural products as mediators of human disease.

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