Waterborne Aripiprazole Blunts the Stress Response in Zebrafish

Overview

Journal Sci Rep

Specialty Science

Date 2016 Nov 23

PMID 27874070

Citations 4

Authors

Heloisa Helena de Alcantara Barcellos

Fabiana Kalichak

Joao Gabriel Santos da Rosa

Thiago Acosta Oliveira

Gessi Koakoski

Renan Idalencio

Murilo Sander de Abreu

Ana Cristina Varrone Giacomini

Michele Fagundes

Cristiane Variani

Mainara Rossini

Angelo L Piato

Leonardo Jose Gil Barcellos

Affiliations

Soon will be listed here.

Abstract

Here we provide, at least to our knowledge, the first evidence that aripiprazole (APPZ) in the water blunts the stress response of exposed fish in a concentration ten times lower than the concentration detected in the environment. Although the mechanism of APPZ in the neuroendocrine axis is not yet determined, our results highlight that the presence of APPZ residues in the environment may interfere with the stress responses in fish. Since an adequate stress response is crucial to restore fish homeostasis after stressors, fish with impaired stress response may have trouble to cope with natural and/or imposed stressors with consequences to their welfare and survival.

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