Ganglioneuroma of the Pancreas in a 4-year-old Girl

Overview

Journal BMJ Case Rep

Specialty General Medicine

Date 2016 Nov 23

PMID 27873762

Citations 2

Authors

Naruhiko Ikoma

Juan A Santamaria-Barria

Curtis Wray

KuoJen Tsao

Affiliations

Soon will be listed here.

Abstract

Ganglioneuroma (GN) is the uncommon, benign representative of the peripheral neuroblastic tumours (PNTs), which arise from primitive sympathetic ganglion cells. PNTs comprise one of the most common groups of neoplastic diseases in infants and children, but its occurrence in the pancreas is rare. We report a 4-year-old girl with GN of the pancreas requiring pancreaticoduodenectomy as a definitive therapy and with a great outcome, and we review the published literature.

Citing Articles

Comments and illustrations of the European Federation of Societies for Ultrasound in Medicine guidelines: Rare pancreatic tumors, ultrasound and contrast-enhanced ultrasound features-Malignant mesenchymal tumors.

Moller K, Ntovas S, Hocke M, On W, Everett S, Braden B Endosc Ultrasound. 2024; 13(2):55-64.

PMID: 38947746 PMC: 11213603. DOI: 10.1097/eus.0000000000000054.

Pancreatic Ganglioneuroma Presenting in an Octogenarian.

Ahmed Shaheen A, Gill I, Edhi A, Amin M, Cappell M ACG Case Rep J. 2021; 8(3):e00546.

PMID: 33763500 PMC: 7984837. DOI: 10.14309/crj.0000000000000546.

References

Christein J, Kim A, Jakate S, Deziel D . Central pancreatectomy for a pancreatic ganglioneuroma in a patient with previous neuroblastoma. Pancreatology. 2002; 2(6):557-60. DOI: 10.1159/000066096. View

Galgano S, Royal S . Primary pancreatic neuroblastoma presenting with opsoclonus-myoclonus syndrome. Radiol Case Rep. 2016; 11(1):36-40. PMC: 4769609. DOI: 10.1016/j.radcr.2015.09.003. View

Shulman D, McClenathan D, Harmel R, Qualman S, ODorisio T . Ganglioneuromatosis involving the small intestine and pancreas of a child and causing hypersecretion of vasoactive intestinal polypeptide. J Pediatr Gastroenterol Nutr. 1996; 22(2):212-8. DOI: 10.1097/00005176-199602000-00015. View

Shimada H, Ambros I, Dehner L, Hata J, JOSHI V, Roald B . Terminology and morphologic criteria of neuroblastic tumors: recommendations by the International Neuroblastoma Pathology Committee. Cancer. 1999; 86(2):349-63. View

Kumar H, Sandoval J, Lovell M, Fenton L, Bealer J . Primary pancreatic neuroblastoma: an unusual tumor in infancy. J Pediatr Surg. 2010; 45(3):642-6. DOI: 10.1016/j.jpedsurg.2009.12.024. View

Shimada H, Ambros I, Dehner L, Hata J, JOSHI V, Roald B . The International Neuroblastoma Pathology Classification (the Shimada system). Cancer. 1999; 86(2):364-72. View

Muller C, Guerin F, Goldzmidt D, Fouquet V, Franchi-Abella S, Fabre M . Pancreatic resections for solid or cystic pancreatic masses in children. J Pediatr Gastroenterol Nutr. 2011; 54(3):369-73. DOI: 10.1097/MPG.0b013e31823cef45. View

Nuchtern J . Perinatal neuroblastoma. Semin Pediatr Surg. 2006; 15(1):10-6. DOI: 10.1053/j.sempedsurg.2005.11.003. View

Shimada H, CHATTEN J, NEWTON Jr W, Sachs N, Hamoudi A, Chiba T . Histopathologic prognostic factors in neuroblastic tumors: definition of subtypes of ganglioneuroblastoma and an age-linked classification of neuroblastomas. J Natl Cancer Inst. 1984; 73(2):405-16. DOI: 10.1093/jnci/73.2.405. View

10.

De Bernardi B, Gambini C, Haupt R, Granata C, Rizzo A, Conte M . Retrospective study of childhood ganglioneuroma. J Clin Oncol. 2008; 26(10):1710-6. DOI: 10.1200/JCO.2006.08.8799. View

11.

Kargl S, Frechinger B, Pumberger W . Perinatal neuroblastoma of the pancreas. Pediatr Surg Int. 2012; 28(12):1239-41. DOI: 10.1007/s00383-012-3179-2. View

12.

Sugito K, Furuya T, Kaneda H, Masuko T, Ohashi K, Inoue M . Long-term follow-up of nutritional status, pancreatic function, and morphological changes of the pancreatic remnant after pancreatic tumor resection in children. Pancreas. 2011; 41(4):554-9. DOI: 10.1097/MPA.0b013e318232a6e2. View

13.

Origone P, Defferrari R, Mazzocco K, Cunsolo C, De Bernardi B, Tonini G . Homozygous inactivation of NF1 gene in a patient with familial NF1 and disseminated neuroblastoma. Am J Med Genet A. 2003; 118A(4):309-13. DOI: 10.1002/ajmg.a.10167. View

14.

Hoeffel J, Galloy M, Schmitt C, Schmitt M . Neuroblastoma of the tail of the pancreas in childhood. Br J Radiol. 1991; 64(758):167-8. DOI: 10.1259/0007-1285-64-758-167. View

15.

Poves I, Burdio F, Iglesias M, Martinez-Serrano M, Aguilar G, Grande L . Resection of the uncinate process of the pancreas due to a ganglioneuroma. World J Gastroenterol. 2009; 15(34):4334-8. PMC: 2744193. DOI: 10.3748/wjg.15.4334. View