A Cell Biological Perspective on Past, Present and Future Investigations of the Spindle Assembly Checkpoint

Overview

Journal Biology (Basel)

Publisher MDPI

Specialty Biology

Date 2016 Nov 22

PMID 27869759

Citations 33

Authors

Ajit P Joglekar

Affiliations

Soon will be listed here.

Abstract

The spindle assembly checkpoint (SAC) is a quality control mechanism that ensures accurate chromosome segregation during cell division. It consists of a mechanochemical signal transduction mechanism that senses the attachment of chromosomes to the spindle, and a signaling cascade that inhibits cell division if one or more chromosomes are not attached. Extensive investigations of both these component systems of the SAC have synthesized a comprehensive understanding of the underlying molecular mechanisms. This review recounts the milestone results that elucidated the SAC, compiles a simple model of the complex molecular machinery underlying the SAC, and highlights poorly understood facets of the biochemical design and cell biological operation of the SAC that will drive research forward in the near future.

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