Protective Immunity to Liver-stage Malaria

Overview

Journal Clin Transl Immunology

Specialty Allergy & Immunology

Date 2016 Nov 22

PMID 27867517

Citations 25

Authors

Lauren E Holz

Daniel Fernandez-Ruiz

William R Heath

Affiliations

Soon will be listed here.

Abstract

Despite decades of research and recent clinical trials, an efficacious long-lasting preventative vaccine for malaria remains elusive. This parasite infects mammals via mosquito bites, progressing through several stages including the relatively short asymptomatic liver stage followed by the more persistent cyclic blood stage, the latter of which is responsible for all disease symptoms. As the liver acts as a bottleneck to blood-stage infection, it represents a potential site for parasite and disease control. In this review, we discuss immunity to liver-stage malaria. It is hoped that the knowledge gained from animal models of malaria immunity will translate into a more powerful and effective vaccine to reduce this global health problem.

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