Renalase As a Novel Biomarker for Evaluating the Severity of Hepatic Ischemia-Reperfusion Injury

Overview

Journal Oxid Med Cell Longev

Publisher Wiley

Specialties Cell Biology
Endocrinology

Date 2016 Nov 22

PMID 27867452

Citations 12

Authors

Huili Li

Jianrong Guo

Hongli Liu

Yanfeng Niu

Lixia Wang

Kun Huang

Jiliang Wang

Affiliations

Soon will be listed here.

Abstract

Hepatic ischemia-reperfusion (I/R) injury is a serious complication in clinical practice. However, no efficient biomarkers are available for the evaluation of the severity of I/R injury. Recently, renalase has been reported to be implicated in the I/R injury of various organs. This protein is secreted into the blood in response to increased oxidative stress. To investigate the responsiveness of renalase to oxidative stress, we examined the changes of renalase in cell and mouse models. We observed a significant increase of renalase expression in HepG2 cells in a time- and dose-dependent manner when treated with HO. Renalase expression also increased significantly in liver tissues that underwent the hepatic I/R process. The increased renalase levels could be efficiently suppressed by antioxidants and . Furthermore, serum renalase levels were significantly increased in the mouse models and also efficiently suppressed by antioxidants treatment. The variation trends are consistent between renalase and liver enzymes in the mouse models. In conclusion, renalase is highly sensitive and responsive to oxidative stress and . Moreover, renalase can be detected in the blood. These properties make renalase a highly promising biomarker for the evaluation of the severity of hepatic I/R injury.

Citing Articles

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Renalase Challenges the Oxidative Stress and Fibroproliferative Response in COVID-19.

Stojanovic D, Stojanovic M, Milenkovic J, Velickov A, Ignjatovic A, Milojkovic M Oxid Med Cell Longev. 2022; 2022:4032704.

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The Scientific Rationale for the Introduction of Renalase in the Concept of Cardiac Fibrosis.

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PMID: 35711341 PMC: 9193824. DOI: 10.3389/fcvm.2022.845878.

The Effect of Renalase rs2576178 and rs10887800 Polymorphisms on Ischemic Stroke Susceptibility in Young Patients (<50 Years): A Case-Control Study and In Silico Analysis.

Ramroodi N, Khorrami A, Hashemi S, Rezaei M, Shahraki-Ghadim H, Salimi S Dis Markers. 2021; 2021:5542292.

PMID: 34603559 PMC: 8483926. DOI: 10.1155/2021/5542292.

The Discriminatory Ability of Renalase and Biomarkers of Cardiac Remodeling for the Prediction of Ischemia in Chronic Heart Failure Patients With the Regard to the Ejection Fraction.

Stojanovic D, Mitic V, Stojanovic M, Petrovic D, Ignjatovic A, Milojkovic M Front Cardiovasc Med. 2021; 8:691513.

PMID: 34395559 PMC: 8358392. DOI: 10.3389/fcvm.2021.691513.

References

Elias-Miro M, Jimenez-Castro M, Rodes J, Peralta C . Current knowledge on oxidative stress in hepatic ischemia/reperfusion. Free Radic Res. 2013; 47(8):555-68. DOI: 10.3109/10715762.2013.811721. View

Lee D, Park S, Bae S, Jeong D, Park M, Kang C . Hydrogen peroxide-activatable antioxidant prodrug as a targeted therapeutic agent for ischemia-reperfusion injury. Sci Rep. 2015; 5:16592. PMC: 4643254. DOI: 10.1038/srep16592. View

Suleyman B, Albayrak A, Kurt N, Demirci E, Gundogdu C, Aksoy M . The effect of etoricoxib on kidney ischemia-reperfusion injury in rats: a biochemical and immunohistochemical assessment. Int Immunopharmacol. 2014; 23(1):179-85. DOI: 10.1016/j.intimp.2014.06.042. View

Opal S, DePalo V . Anti-inflammatory cytokines. Chest. 2000; 117(4):1162-72. DOI: 10.1378/chest.117.4.1162. View

Kunak C, Kukula O, Mutlu E, Genc F, Peker G, Kuyrukluyildiz U . The Effect of Etoricoxib on Hepatic Ischemia-Reperfusion Injury in Rats. Oxid Med Cell Longev. 2015; 2015:598162. PMC: 4506808. DOI: 10.1155/2015/598162. View

Abe Y, Hines I, Zibari G, Pavlick K, Gray L, Kitagawa Y . Mouse model of liver ischemia and reperfusion injury: method for studying reactive oxygen and nitrogen metabolites in vivo. Free Radic Biol Med. 2008; 46(1):1-7. PMC: 2740994. DOI: 10.1016/j.freeradbiomed.2008.09.029. View

Deng Y, Zhao L, Lu X . A multidrug cocktail approach attenuates ischemic-type biliary lesions in liver transplantation from non-heart-beating donors. Med Hypotheses. 2016; 91:47-52. DOI: 10.1016/j.mehy.2016.04.013. View

Moreno-Ruiz L, Ibarra-Quevedo D, Rodriguez-Martinez E, Maldonado P, Sarabia-Ortega B, Hernandez-Martinez J . Oxidative Stress State Is Associated with Left Ventricular Mechanics Changes, Measured by Speckle Tracking in Essential Hypertensive Patients. Oxid Med Cell Longev. 2015; 2015:502107. PMC: 4609485. DOI: 10.1155/2015/502107. View

Du M, Huang K, Huang D, Yang L, Gao L, Wang X . Renalase is a novel target gene of hypoxia-inducible factor-1 in protection against cardiac ischaemia-reperfusion injury. Cardiovasc Res. 2014; 105(2):182-91. DOI: 10.1093/cvr/cvu255. View

10.

Eltzschig H, Collard C . Vascular ischaemia and reperfusion injury. Br Med Bull. 2004; 70:71-86. DOI: 10.1093/bmb/ldh025. View

11.

Dinarello C . Proinflammatory cytokines. Chest. 2000; 118(2):503-8. DOI: 10.1378/chest.118.2.503. View

12.

Pinelli A, Trivulzio S, Brenna S, Rossoni G . Plasma cardiac necrosis markers C-troponin I and creatine kinase, associated with increased malondialdehyde levels, induced in rabbits by means of 5-aminolevulinic acid injection. Pharmacology. 2009; 84(5):314-21. DOI: 10.1159/000248216. View

13.

Ma S, Nishikawa M, Katsumi H, Yamashita F, Hashida M . Liver targeting of catalase by cationization for prevention of acute liver failure in mice. J Control Release. 2005; 110(2):273-282. DOI: 10.1016/j.jconrel.2005.10.016. View

14.

Moran G . The catalytic function of renalase: A decade of phantoms. Biochim Biophys Acta. 2015; 1864(1):177-86. DOI: 10.1016/j.bbapap.2015.04.010. View

15.

Yu J, Lee H, Lee S, Yu H, Moon W, Chung M . Aggravation of post-ischemic liver injury by overexpression of A20, an NF-κB suppressor. J Hepatol. 2010; 55(2):328-36. DOI: 10.1016/j.jhep.2010.11.029. View

16.

Chamoun F, Burne M, ODonnell M, Rabb H . Pathophysiologic role of selectins and their ligands in ischemia reperfusion injury. Front Biosci. 2000; 5:E103-9. DOI: 10.2741/chamoun. View

17.

Guillen I, Blanes M, Gomez-Lechon M, Castell J . Cytokine signaling during myocardial infarction: sequential appearance of IL-1 beta and IL-6. Am J Physiol. 1995; 269(2 Pt 2):R229-35. DOI: 10.1152/ajpregu.1995.269.2.R229. View

18.

Lykkesfeldt J, Loft S, Poulsen H . Determination of ascorbic acid and dehydroascorbic acid in plasma by high-performance liquid chromatography with coulometric detection--are they reliable biomarkers of oxidative stress?. Anal Biochem. 1995; 229(2):329-35. DOI: 10.1006/abio.1995.1421. View

19.

Malyszko J, Bachorzewska-Gajewska H, Dobrzycki S . Renalase, kidney and cardiovascular disease: are they related or just coincidentally associated?. Adv Med Sci. 2014; 60(1):41-9. DOI: 10.1016/j.advms.2014.10.001. View

20.

Yang Q, Wu W, Li Q, Chen C, Zhou R, Qiu Y . High-Dose Polymerized Hemoglobin Fails to Alleviate Cardiac Ischemia/Reperfusion Injury due to Induction of Oxidative Damage in Coronary Artery. Oxid Med Cell Longev. 2015; 2015:125106. PMC: 4487275. DOI: 10.1155/2015/125106. View