Screening for Pancreatic Cancer
Overview
Affiliations
Pancreatic cancer (PC) is a highly fatal disease that can only be cured by complete surgical resection. However, most patients with PC have unresectable disease at the time of diagnosis, highlighting the need to detect PC and its precursor lesions earlier in asymptomatic patients. Screening is not cost-effective for population-based screening of PC. Individuals with genetic risk factors for PC based on family history or known PC-associated genetic syndromes, however, can be a potential target for PC screening programs. This article provides an overview of the epidemiology and genetic background of familial PC and discusses diagnostic and management approaches.
Pancreatic cancer detection with a non-contrast MR protocol: is it reliable?.
Maio F, Pasqualino V, Bertana L, Venturini S, Cantoni V, Fusaro M Radiol Med. 2023; 128(9):1035-1046.
PMID: 37515631 PMC: 10474201. DOI: 10.1007/s11547-023-01680-z.
Saba H, Goggins M Gastroenterol Clin North Am. 2022; 51(3):561-575.
PMID: 36153110 PMC: 11095833. DOI: 10.1016/j.gtc.2022.06.006.
Cell-free DNA TAPS provides multimodal information for early cancer detection.
Siejka-Zielinska P, Cheng J, Jackson F, Liu Y, Soonawalla Z, Reddy S Sci Adv. 2021; 7(36):eabh0534.
PMID: 34516908 PMC: 8442905. DOI: 10.1126/sciadv.abh0534.
Signature of gene aberrant alternative splicing events in pancreatic adenocarcinoma prognosis.
Yao J, Tang Y, Yi B, Yang J, Chai Y, Yin N J Cancer. 2021; 12(11):3164-3179.
PMID: 33976726 PMC: 8100795. DOI: 10.7150/jca.48661.
Kulkarni N, Mannelli L, Zins M, Bhosale P, Arif-Tiwari H, Brook O Abdom Radiol (NY). 2019; 45(3):729-742.
PMID: 31768594 DOI: 10.1007/s00261-019-02290-y.