Profile of Charles M. Rice, Ralf F. W. Bartenschlager, and Michael J. Sofia, 2016 Lasker-DeBakey Clinical Medical Research Awardees

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 2016 Nov 20

PMID 27864510

Citations 1

Authors

Peter Palese

Affiliations

Soon will be listed here.

Citing Articles

Public funding for transformative drugs: the case of sofosbuvir.

Barenie R, Avorn J, Tessema F, Kesselheim A Drug Discov Today. 2020; 26(1):273-281.

PMID: 33011345 PMC: 7528745. DOI: 10.1016/j.drudis.2020.09.024.

References

Wang P, Chun B, Rachakonda S, Du J, Khan N, Shi J . An efficient and diastereoselective synthesis of PSI-6130: a clinically efficacious inhibitor of HCV NS5B polymerase. J Org Chem. 2009; 74(17):6819-24. DOI: 10.1021/jo901345j. View

Kolykhalov A, Feinstone S, Rice C . Identification of a highly conserved sequence element at the 3' terminus of hepatitis C virus genome RNA. J Virol. 1996; 70(6):3363-71. PMC: 190207. DOI: 10.1128/JVI.70.6.3363-3371.1996. View

Bartenschlager R, Lohmann V . Replication of hepatitis C virus. J Gen Virol. 2000; 81(Pt 7):1631-48. DOI: 10.1099/0022-1317-81-7-1631. View

Kolykhalov A, Agapov E, Blight K, Mihalik K, Feinstone S, Rice C . Transmission of hepatitis C by intrahepatic inoculation with transcribed RNA. Science. 1997; 277(5325):570-4. DOI: 10.1126/science.277.5325.570. View

Lohmann V, KORNER F, Koch J, Herian U, Theilmann L, Bartenschlager R . Replication of subgenomic hepatitis C virus RNAs in a hepatoma cell line. Science. 1999; 285(5424):110-3. DOI: 10.1126/science.285.5424.110. View

Krieger N, Lohmann V, Bartenschlager R . Enhancement of hepatitis C virus RNA replication by cell culture-adaptive mutations. J Virol. 2001; 75(10):4614-24. PMC: 114214. DOI: 10.1128/JVI.75.10.4614-4624.2001. View

Rice C, Levis R, Strauss J, Huang H . Production of infectious RNA transcripts from Sindbis virus cDNA clones: mapping of lethal mutations, rescue of a temperature-sensitive marker, and in vitro mutagenesis to generate defined mutants. J Virol. 1987; 61(12):3809-19. PMC: 255997. DOI: 10.1128/JVI.61.12.3809-3819.1987. View

Blight K, Kolykhalov A, Reed K, Agapov E, Rice C . Molecular virology of hepatitis C virus: an update with respect to potential antiviral targets. Antivir Ther. 2000; 3(Suppl 3):71-81. View

Sofia M, Bao D, Chang W, Du J, Nagarathnam D, Rachakonda S . Discovery of a β-d-2'-deoxy-2'-α-fluoro-2'-β-C-methyluridine nucleotide prodrug (PSI-7977) for the treatment of hepatitis C virus. J Med Chem. 2010; 53(19):7202-18. DOI: 10.1021/jm100863x. View

10.

Wakita T, Pietschmann T, Kato T, Date T, Miyamoto M, Zhao Z . Production of infectious hepatitis C virus in tissue culture from a cloned viral genome. Nat Med. 2005; 11(7):791-6. PMC: 2918402. DOI: 10.1038/nm1268. View