Nordihydroguaiaretic Acid Impairs Prostate Cancer Cell Migration and Tumor Metastasis by Suppressing Neuropilin 1

Overview

Journal Oncotarget

Specialty Oncology

Date 2016 Nov 19

PMID 27863391

Citations 17

Authors

Xin Li

Shengjun Fan

Xueyang Pan

Yilixiati Xiaokaiti

Jianhui Duan

Yundi Shi

Yan Pan

Lu Tie

Xin Wang

Yuhua Li

Xuejun Li

Affiliations

Soon will be listed here.

Abstract

Tumor metastasis is a major cause leading to the deaths of cancer patients. Nordihydroguaiaretic acid (NDGA) is a natural product that has been demonstrated to show therapeutic values in multiple diseases. In this study, we report that NDGA can inhibit cell migration and tumor metastasis via a novel mechanism. NDGA suppresses NRP1 function by downregulating its expression, which leads to attenuated cell motility, cell adhesion to ECM and FAK signaling in cancer cells. Moreover, due to its cross-cell type activity on NRP1 suppression, NDGA also impairs angiogenesis function of endothelial cells and fibronectin assembly by fibroblasts, both of which are critical to promote metastasis. Based on these comprehensive effects, NDGA effectively suppresses tumor metastasis in nude mice model. Our findings reveal a novel mechanism underlying the anti-metastasis function of NDGA and indicate the potential value of NDGA in NRP1 targeting therapy for selected subtypes of cancer.

Citing Articles

Impact of Nordihydroguaiaretic Acid on Proliferation, Energy Metabolism, and Chemosensitization in Non-Small-Cell Lung Cancer (NSCLC) Cell Lines.

Chipon C, Riffo P, Ojeda L, Salas M, Burgos R, Ehrenfeld P Int J Mol Sci. 2024; 25(21).

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Dietary Polyphenols Effects on Focal Adhesion Plaques and Metalloproteinases in Cancer Invasiveness.

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Nordihydroguaiaretic Acid Affects Undifferentiated and Differentiated Neuroblastoma Cells Differently through Mechanisms that Impact on Cell Viability.

Ferrera P, De la Fuente-Munoz C, Arias C CNS Neurol Disord Drug Targets. 2023; 23(9):1167-1175.

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Phytochemicals Showing Antiangiogenic Effect in Pre-clinical Models and their Potential as an Alternative to Existing Therapeutics.

Senrung A, Tripathi T, Aggarwal N, Janjua D, Yadav J, Chaudhary A Curr Top Med Chem. 2023; 24(4):259-300.

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Neuropilin-1 Knockout and Rescue Confirms Its Role to Promote Metastasis in MDA-MB-231 Breast Cancer Cells.

Al-Zeheimi N, Gao Y, Greer P, Adham S Int J Mol Sci. 2023; 24(9).

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