Incoming Human Papillomavirus 16 Genome is Lost in PML Protein-deficient HaCaT Keratinocytes

Overview

Journal Cell Microbiol

Publisher Wiley

Specialties Cell Biology
Microbiology

Date 2016 Nov 19

PMID 27860076

Citations 19

Authors

Malgorzata Bienkowska-Haba

Wioleta Luszczek

Timothy R Keiffer

Lucile G M Guion

Stephen DiGiuseppe

Rona S Scott

Martin Sapp

Affiliations

Soon will be listed here.

Abstract

Importance: Promyelocytic leukemia nuclear bodies (PML NBs) are important for antiviral defense. Many DNA viruses target these subnuclear structures and reorganize them. Reorganization of PML NBs by viral proteins is important for establishment of infection. In contrast, HPVs require the presence of PML protein for efficient transcription of incoming viral genome. Our finding that PML protein prevents the loss of HPV genome following infection implies that the host cell may be able to recognize chromatinized HPV genome or the associated capsid proteins. A constitutively active interferon response in absence of PML protein suggests that PML NBs are key regulators of the innate immune response in keratinocytes.

Citing Articles

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