Plasma Selenium Levels and Nonalcoholic Fatty Liver Disease in Chinese Adults: a Cross-sectional Analysis

Overview

Journal Sci Rep

Specialty Science

Date 2016 Nov 18

PMID 27853246

Citations 33

Authors

Zhen Yang

Chonghuai Yan

Gang Liu

Yixin Niu

Weiwei Zhang

Shuai Lu

Xiaoyong Li

Hongmei Zhang

Guang Ning

Jiangao Fan

Li Qin

Qing Su

Affiliations

Soon will be listed here.

Abstract

Selenium exposure can induce liver insulin resistance and increased liver triglyceride concentrations in animals, which may link to an increased risk of nonalcoholic fatty liver disease (NAFLD). However, epidemiological studies investigating the association between elevated plasma selenium levels and NAFLD were not available. We aimed to investigate the association of selenium levels with the prevalence of NAFLD in Chinese adults. This was a cross-sectional study of 8550 Chinese adults aged 40 yr or older in Shanghai, China. A questionnaire, anthropometric measurements, and laboratory tests were conducted. NAFLD was diagnosed by hepatic ultrasound after the exclusion of alcohol abuse and other liver diseases. Plasma selenium concentration was assessed by inductively coupled plasma mass spectroscopy. The median concentration of plasma selenium was 213.0 μg/L. Elevated plasma selenium levels were associated with higher triglycerides, LDL-cholesterol, fasting plasma glucose, post-loading plasma glucose, A1c, HOMA-IR, as well as ALT, AST and γ-GT (all P < 0.05). The odds ratios were substantially higher for NAFLD (OR = 1.54, 95% CI 1.13-2.18) in the highest selenium quartile compared with those in the lowest quartile, after adjustment for potential cofounder. The results of this study provided epidemiological evidence that increased plasma selenium level is associated with elevated prevalence of NAFLD.

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