Analysis of a Surface Antigen of Pneumocystis Carinii

Overview

Journal J Protozool

Specialties Microbiology
Parasitology

Date 1989 Jan 1

PMID 2785200

Citations 7

Authors

M J Linke

P D Walzer

Affiliations

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Abstract

The 115 kd band in polyacrylamide gels is a major antigen of Pneumocystis carinii. Data obtained from treatment with enzymes, binding to lectins, and labelling the surface with biotin suggest that this moiety is a glycoprotein containing mannosyl/glucosyl and N-acetylglucosamine residues, and that it is located on the cell wall of the organism. Other rat and human P. carinii antigens also are glycoproteins but differ in specific protein or carbohydrate residues or location on the organism.

Citing Articles

A Molecular Window into the Biology and Epidemiology of Pneumocystis spp.

Ma L, Cisse O, Kovacs J Clin Microbiol Rev. 2018; 31(3).

PMID: 29899010 PMC: 6056843. DOI: 10.1128/CMR.00009-18.

Gene arrays at Pneumocystis carinii telomeres.

Keely S, Renauld H, Wakefield A, Cushion M, Smulian A, Fosker N Genetics. 2005; 170(4):1589-600.

PMID: 15965256 PMC: 1449779. DOI: 10.1534/genetics.105.040733.

Diversity at the locus associated with transcription of a variable surface antigen of Pneumocystis carinii as an index of population structure and dynamics in infected rats.

Keely S, Cushion M, Stringer J Infect Immun. 2002; 71(1):47-60.

PMID: 12496148 PMC: 143281. DOI: 10.1128/IAI.71.1.47-60.2003.

Genetics of surface antigen expression in Pneumocystis carinii.

Stringer J, Keely S Infect Immun. 2001; 69(2):627-39.

PMID: 11159949 PMC: 97933. DOI: 10.1128/IAI.69.2.627-639.2001.

Identification of a putative precursor to the major surface glycoprotein of Pneumocystis carinii.

Sunkin S, Linke M, McCormack F, Walzer P, Stringer J Infect Immun. 1998; 66(2):741-6.

PMID: 9453635 PMC: 113502. DOI: 10.1128/IAI.66.2.741-746.1998.