[Clinical Importance of HDL Cholesterol]

Overview

Journal Herz

Specialty Cardiology & Vascular Diseases

Date 2016 Nov 16

PMID 27844137

Citations 5

Authors

W Marz

M E Kleber

H Scharnagl

T Speer

S Zewinger

A Ritsch

K G Parhofer

A von Eckardstein

U Landmesser

U Laufs

Affiliations

Soon will be listed here.

Abstract

Backround: Each year 16-17 million determinations of high-density lipoprotein cholesterol (HDL-C) are conducted and interpreted in Germany. Recently acquired data have led to a fundamental reassessment of the clinical significance of HDL-C.

Method: This review article is based on a selective literature search.

Results: Low HDL‑C levels usually indicate an increased cardiovascular risk, particularly in primary prevention but the epidemiological relationship between HDL‑C and the risk is complex. The HDL plays a role in the back transport and excretion of cholesterol; however, the biological functions of HDL are dependent on the protein and lipid composition, which is not reflected by the HDL‑C concentration. If the composition of HDL is pathologically altered it can also exert negative vascular effects.

Conclusion: Compared with low-density lipoprotein cholesterol (LDL-C), HDL‑C is of secondary importance for cardiovascular risk stratification and the calculation of the LDL-C:HDL‑C ratio is not useful for all patients. Low HDL‑C levels should prompt a search for additional metabolic and inflammatory pathologies. An increase in HDL‑C through lifestyle changes (e.g. smoking cessation and physical exercise) has positive effects and is recommended; however, HDL‑C is currently not a valid target for drug therapy.

Citing Articles

[Laboratory diagnostics of lipid metabolism disorders].

Marz W, Scharnagl H, Kleber M, Silbernagel G, Nauck M, Muller-Wieland D Dtsch Med Wochenschr. 2023; 148(23):e120-e146.

PMID: 37949074 PMC: 10637831. DOI: 10.1055/a-1516-2511.

Prevalence of High HDL Cholesterol and Its Associated Factors Among Tunisian Women of Childbearing Age: A Cross-Sectional Study.

Ben Cherifa F, El Ati J, Doggui R, El Ati-Hellal M, Traissac P Int J Environ Res Public Health. 2021; 18(10).

PMID: 34065252 PMC: 8160772. DOI: 10.3390/ijerph18105461.

Walking activity during ambulant cardiac rehabilitation is related to maximum working capacity, age, and smoking behavior.

Najem S, Groll A, Schmermund A, Nowak B, Voigtlander T, Kaltenbach U Vasc Health Risk Manag. 2018; 14:361-369.

PMID: 30519032 PMC: 6235325. DOI: 10.2147/VHRM.S179798.

[Congenital disorders of lipoprotein metabolism].

Marz W, Grammer T, Delgado G, Kleber M Herz. 2017; 42(5):449-458.

PMID: 28555288 DOI: 10.1007/s00059-017-4578-x.

HDL cholesterol: reappraisal of its clinical relevance.

Marz W, Kleber M, Scharnagl H, Speer T, Zewinger S, Ritsch A Clin Res Cardiol. 2017; 106(9):663-675.

PMID: 28342064 PMC: 5565659. DOI: 10.1007/s00392-017-1106-1.

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