Association Between and Polymorphisms and Susceptibility to Methamphetamine Dependence

Overview

Journal Mol Biol Res Commun

Specialty Molecular Biology

Date 2016 Nov 16

PMID 27843993

Citations 4

Authors

Mohammad Rashid Khalighinasab

Khyber Saify

Mostafa Saadat

Affiliations

Soon will be listed here.

Abstract

Glutathione S-transferases (GSTs; EC: 2.5.1.18) are ubiquitous multifunctional enzymes, which play a key role in cellular detoxification. Functional genetic polymorphisms in genes encoding (a member of GST class mu; OMIM: 138350), and (a member of GST class theta; OMIM: 600436) have been well defined. The functional null alleles of GSTM1 and represent deletions of and genes, respectively. The aim of the present study is to investigate the association between and polymorphisms and methamphetamine dependence. The present population-based case-control study was performed in Shiraz (southern Iran). In total, 52 methamphetamine dependence (11 females, 41 males) and 635 healthy controls (110 females, 525 males) were included in this study. The genotypes of and polymorphisms were determined by PCR. Neither (OR=0.92, 95% CI: 0.52-1.61, P=0.771) nor (OR=0.71, 95% CI: 0.33-1.54, P=0.381) null genotypes were significantly associated with risk of methamphetamine dependence. It should be noted that although there was no association between the null genotype and risk of methamphetamine dependence, in both genders, there was significant interaction between gender and polymorphism (P=0.029). The combination genotypes of the and polymorphisms revealed that the genotypes of these two polymorphisms had no additive effect in relation to the susceptibility to methamphetamine dependence. The present study revealed that genetic polymorphisms of and are not risk factors for methamphetamine dependence.

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