Biochemical Hyperthyroidism in a Newborn Baby Caused by Assay Interaction from Biotin Intake

Overview

Journal Eur Thyroid J

Specialties Endocrinology
Oncology

Date 2016 Nov 16

PMID 27843813

Citations 7

Authors

Inge Bulow Pedersen

Peter Laurberg

Affiliations

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Abstract

We describe a case of biochemical neonatal thyrotoxicosis caused by biotin supplementation. Biotin may interact with thyroid function testing to imitate thyrotoxicosis with low thyroid-stimulating hormone and elevated triiodothyronine and thyroxine levels.

Citing Articles

Pseudo-hyperthyroidism: Biotin interference in a case with renal failure.

Demiral M, Kiraz Z, Alatas I, Cetin N, Kirel B Acta Endocrinol (Buchar). 2022; 17(3):319-322.

PMID: 35342468 PMC: 8919483. DOI: 10.4183/aeb.2021.319.

A Neonate with a Diagnosis of Pontocerebellar Hypoplasia Type 6 Treated with Biotin and Developed Biotin Interference with Laboratory Thyroid Function Tests.

Nagafuji M, Hitaka D, Iwabuchi A, Miyazono Y, Takada H Am J Case Rep. 2021; 22:e934417.

PMID: 34930889 PMC: 8711254. DOI: 10.12659/AJCR.934417.

Hormone Immunoassay Interference: A 2021 Update.

Ghazal K, Brabant S, Prie D, Piketty M Ann Lab Med. 2021; 42(1):3-23.

PMID: 34374345 PMC: 8368230. DOI: 10.3343/alm.2022.42.1.3.

When thyroid labs do not add up, physicians should ask patients about biotin supplements.

Lundin M, Alratroot A, Rous F, Aldasouqi S BMJ Case Rep. 2020; 13(3).

PMID: 32234851 PMC: 7167425. DOI: 10.1136/bcr-2019-231337.

Effect of High-dose Biotin on Thyroid Function Tests: Case Report and Literature Review.

Ardabilygazir A, Afshariyamchlou S, Mir D, Sachmechi I Cureus. 2018; 10(6):e2845.

PMID: 30140596 PMC: 6103391. DOI: 10.7759/cureus.2845.

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