Left Ventricular Function Assessment Using I/Tc Dual-isotope Acquisition with Two Semi-conductor Cadmium-zinc-telluride (CZT) Cameras: a Gated Cardiac Phantom Study

Overview

Journal EJNMMI Phys

Specialty Radiology

Date 2016 Nov 13

PMID 27837548

Citations 6

Authors

Tanguy Blaire

Alban Bailliez

Faycal Ben Bouallegue

Dimitri Bellevre

Denis Agostini

Alain Manrique

Affiliations

Soon will be listed here.

Abstract

Background: The impact of increased energy resolution of cadmium-zinc-telluride (CZT) cameras on the assessment of left ventricular function under dual-isotope conditions (Tc and I) remains unknown. The Amsterdam-gated dynamic cardiac phantom (AGATE, Vanderwilt techniques, Boxtel, The Netherlands) was successively filled with a solution of I alone, Tc alone, and a mixture of I and Tc. A total of 12 datasets was acquired with each commercially available CZT camera (DNM 530c, GE Healthcare and DSPECT, Biosensors International) using both energy windows (Tc or I) with ejection fraction set to 33, 45, and 60 %. End-diastolic (EDV) and end-systolic (ESV) volumes, ejection fraction (LVEF), and regional wall motion and thickening (17-segment model) were assessed using Cedars-Sinai QGS Software. Concordance between single- and dual-isotope acquisitions was tested using Lin's concordance correlation coefficient (CCC) and Bland-Altman plots.

Results: There was no significant difference between single- or simultaneous dual-isotope acquisition (I and Tc) for EDV, ESV, LVEF, or segmental wall motion and thickening. Myocardial volumes using single- (I, Tc) and dual-isotope (reconstructed using both I and Tc energy windows) acquisitions were, respectively, the following: EDV (mL) 88 ± 27 vs. 89 ± 27 vs. 92 ± 29 vs. 90 ± 26 for DNM 530c (p = NS) and 82 ± 20 vs. 83 ± 22 vs. 79 ± 19 vs. 77 ± 20 for DSPECT (p = NS); ESV (mL) 40 ± 1 vs. 41 ± 2 vs. 41 ± 2 vs. 42 ± 1 for DNM 530c (p = NS) and 37 ± 5 vs. 37 ± 1 vs. 35 ± 3 vs. 34 ± 2 for DSPECT (p = NS); LVEF (%) 52 ± 14 vs. 51 ± 13 vs. 53 ± 13 vs. 51 ± 13 for DNM 530c (p = NS) and 52 ± 16 vs. 54 ± 13 vs. 54 ± 14 vs. 54 ± 13 for DSPECT (p = NS); regional motion (mm) 6.72 ± 2.82 vs. 6.58 ± 2.52 vs. 6.86 ± 2.99 vs. 6.59 ± 2.76 for DNM 530c (p = NS) and 6.79 ± 3.17 vs. 6.81 ± 2.75 vs. 6.71 ± 2.50 vs. 6.62 ± 2.74 for DSPECT (p = NS). The type of camera significantly impacted only on ESV (p < 0.001).

Conclusions: The new CZT cameras yielded similar results for the assessment of LVEF and regional motion using different energy windows (I or Tc) and acquisition types (single vs. dual). With simultaneous dual-isotope acquisitions, the presence of I did not impact on LVEF assessment within the Tc energy window for either CZT camera.

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