Pediatric Hematopoietic Stem Cell Transplantation in India: Status, Challenges and the Way Forward : Based on Dr. K. C. Chaudhuri Oration 2016

Overview

Journal Indian J Pediatr

Specialty Pediatrics

Date 2016 Nov 11

PMID 27832477

Citations 2

Authors

Vineet Govinda Gupta

Sameer Bakhshi

Affiliations

Soon will be listed here.

Abstract

Hematopoietic stem cell transplantation (HSCT) refers to therapies that aim to eliminate a patient's hematopoietic and immune system and replace it with his own (autologous) or someone else's (allogenic) system. The applications of this therapy are vast and growing, and include several malignant and benign diseases incurable by any other existing modalities. Pediatric patients constitute a minority of HSCT recipients with unique concerns. Despite substantial progress in the last two decades, limitations due to financial, infrastructural, manpower and research constraints act as barriers to fulfilling the large need for pediatric HSCT services in our country. Limited availability of unrelated donors and cord blood units is another constraint. Here in this oration, we discuss the current issues pertaining to pediatric HSCT in India and describe our experience with the same.

Citing Articles

Combined Metronomic Chemo-immunotherapy (CMCI) in Head and Neck Cancers-An Experience from a Developing Country.

Madabhavi I, Sarkar M, Kumar V, Sagar R Indian J Surg Oncol. 2024; 15(2):321-331.

PMID: 38741631 PMC: 11088580. DOI: 10.1007/s13193-024-01900-6.

Immune checkpoint inhibitors: Real-world experience from India in advanced solid cancers that have progressed on chemotherapy.

Gupta V, Rangaraju R, Abbas W, Bajpai P, Khetrapal R South Asian J Cancer. 2019; 8(1):65-68.

PMID: 30766859 PMC: 6348784. DOI: 10.4103/sajc.sajc_167_18.

References

van Laar J, Sullivan K . Stem cell transplantation in systemic sclerosis. Curr Opin Rheumatol. 2013; 25(6):719-25. DOI: 10.1097/01.bor.0000434669.32150.ac. View

Kumar R, Naithani R, Mishra P, Mahapatra M, Seth T, Dolai T . Allogeneic hematopoietic SCT performed in non-HEPA filter rooms: initial experience from a single center in India. Bone Marrow Transplant. 2008; 43(2):115-9. DOI: 10.1038/bmt.2008.307. View

Shah S, Shah K, Patel K, Anand A, Talati S, Panchal H . Unrelated Umbilical Cord Blood Transplant for Children with β-Thalassemia Major. Indian J Hematol Blood Transfus. 2014; 31(1):9-13. PMC: 4275517. DOI: 10.1007/s12288-014-0391-3. View

Sharma S, Choudhary D, Gupta N, Dhamija M, Khandelwal V, Kharya G . Cost of hematopoietic stem cell transplantation in India. Mediterr J Hematol Infect Dis. 2014; 6(1):e2014046. PMC: 4103507. DOI: 10.4084/MJHID.2014.046. View

Switzer G, Bruce J, Myaskovsky L, DiMartini A, Shellmer D, Confer D . Race and ethnicity in decisions about unrelated hematopoietic stem cell donation. Blood. 2012; 121(8):1469-76. PMC: 3578960. DOI: 10.1182/blood-2012-06-437343. View

Kekre N, Antin J . Hematopoietic stem cell transplantation donor sources in the 21st century: choosing the ideal donor when a perfect match does not exist. Blood. 2014; 124(3):334-43. DOI: 10.1182/blood-2014-02-514760. View

Yadav S, Sachdeva A . Pediatric allogeneic stem cell transplantation: experience from the developing world. Pediatr Hematol Oncol. 2013; 31(3):205-6. DOI: 10.3109/08880018.2013.790526. View

Chandy M, Srivastava A, Dennison D, Mathews V, George B . Allogeneic bone marrow transplantation in the developing world: experience from a center in India. Bone Marrow Transplant. 2001; 27(8):785-90. DOI: 10.1038/sj.bmt.1702869. View

George B, Mathews V, Srivastava A, Chandy M . Infections among allogeneic bone marrow transplant recipients in India. Bone Marrow Transplant. 2003; 33(3):311-5. DOI: 10.1038/sj.bmt.1704347. View

10.

Shah C, Karanwal A, Desai M, Pandya M, Shah R, Shah R . Hematopoietic stem-cell transplantation in the developing world: experience from a center in Western India. J Oncol. 2015; 2015:710543. PMC: 4333194. DOI: 10.1155/2015/710543. View

11.

Bahl A, Bakhshi S . Umbilical cord blood transplant for malignancies: a hope or hype. Indian J Pediatr. 2013; 80(8):675-80. DOI: 10.1007/s12098-013-1046-3. View

12.

Maiers M, Halagan M, Joshi S, Ballal H, Jagannatthan L, Damodar S . HLA match likelihoods for Indian patients seeking unrelated donor transplantation grafts: a population-based study. Lancet Haematol. 2016; 1(2):e57-63. DOI: 10.1016/S2352-3026(14)70021-3. View

13.

Barnes D, CORP M, LOUTIT J, NEAL F . Treatment of murine leukaemia with X rays and homologous bone marrow; preliminary communication. Br Med J. 1956; 2(4993):626-7. PMC: 2035298. DOI: 10.1136/bmj.2.4993.626. View

14.

George B, Mathews V, Viswabandya A, Lakshmi K, Srivastava A, Chandy M . Allogeneic hematopoietic stem cell transplantation is superior to immunosuppressive therapy in Indian children with aplastic anemia--a single-center analysis of 100 patients. Pediatr Hematol Oncol. 2010; 27(2):122-31. DOI: 10.3109/08880010903540542. View

15.

Margini C, Vukotic R, Brodosi L, Bernardi M, Andreone P . Bone marrow derived stem cells for the treatment of end-stage liver disease. World J Gastroenterol. 2014; 20(27):9098-105. PMC: 4112892. DOI: 10.3748/wjg.v20.i27.9098. View

16.

Copelan E . Hematopoietic stem-cell transplantation. N Engl J Med. 2006; 354(17):1813-26. DOI: 10.1056/NEJMra052638. View

17.

Mitchell J, Meehan K, Kong J, Schulman K . Access to bone marrow transplantation for leukemia and lymphoma: the role of sociodemographic factors. J Clin Oncol. 1997; 15(7):2644-51. DOI: 10.1200/JCO.1997.15.7.2644. View

18.

Weiss R, GILL G, Hudis C . An on-site audit of the South African trial of high-dose chemotherapy for metastatic breast cancer and associated publications. J Clin Oncol. 2001; 19(11):2771-7. DOI: 10.1200/JCO.2001.19.11.2771. View

19.

Lucarelli G, Galimberti M, Polchi P, Angelucci E, Baronciani D, Giardini C . Marrow transplantation in patients with thalassemia responsive to iron chelation therapy. N Engl J Med. 1993; 329(12):840-4. DOI: 10.1056/NEJM199309163291204. View

20.

Kayal S, Sharma A, Iqbal S, Tejomurtula T, Cyriac S, Raina V . High-dose chemotherapy and autologous stem cell transplantation in multiple myeloma: a single institution experience at All India Institute of Medical Sciences, New Delhi, using non-cryopreserved peripheral blood stem cells. Clin Lymphoma Myeloma Leuk. 2013; 14(2):140-7. DOI: 10.1016/j.clml.2013.09.001. View