Cannabinoids in the Management of Musculoskeletal or Rheumatic Diseases
Overview
Authors
Affiliations
The endocannabinoid system impacts pain and inflammation with potential for therapeutic effect on patients with rheumatic diseases. The current treatment options include the herbal product derived from the plant Cannabis sativa, as well as pharmaceutical preparations. The legalization of medicinal cannabis (marijuana) in many jurisdictions and widespread public advocacy has propelled an interest in use either by prescription or self-medication. In this review, we examine current evidence for efficacy and adverse effects of any cannabinoid product in rheumatic conditions. The evidence to date is scant and precludes making recommendations for the use of cannabinoid preparations in rheumatology patients. In particular, the risks of herbal cannabis in patients are not well defined. Anecdote and advocacy cannot supersede sound evidence.
Rosenbaek F, Riisgaard H, Nielsen J, Wehberg S, Waldorff F, Pedersen L BMC Prim Care. 2023; 24(1):17.
PMID: 36650442 PMC: 9843989. DOI: 10.1186/s12875-023-01971-4.
Jennings J, McNabb D, Johnson R, Brady A, Kim R, Dennis D Arthroplast Today. 2022; 15:141-146.
PMID: 35586610 PMC: 9108508. DOI: 10.1016/j.artd.2022.03.018.
Cannabis for Rheumatic Disease Pain: a Review of Current Literature.
Nowell W, Gavigan K, Silverman S Curr Rheumatol Rep. 2022; 24(5):119-131.
PMID: 35486218 DOI: 10.1007/s11926-022-01065-7.
Cannabis and pain: a scoping review.
Pantoja-Ruiz C, Restrepo-Jimenez P, Castaneda-Cardona C, Ferreiros A, Rosselli D Braz J Anesthesiol. 2021; 72(1):142-151.
PMID: 34280454 PMC: 9373074. DOI: 10.1016/j.bjane.2021.06.018.
Cannabinoid Use in Musculoskeletal Illness: a Review of the Current Evidence.
OConnor C, Anoushiravani A, Adams C, Young J, Richardson K, Rosenbaum A Curr Rev Musculoskelet Med. 2020; 13(4):379-384.
PMID: 32383037 PMC: 7340702. DOI: 10.1007/s12178-020-09635-x.