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Cannabinoids in the Management of Musculoskeletal or Rheumatic Diseases

Overview
Publisher Current Science
Specialty Rheumatology
Date 2016 Nov 11
PMID 27832442
Citations 7
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Abstract

The endocannabinoid system impacts pain and inflammation with potential for therapeutic effect on patients with rheumatic diseases. The current treatment options include the herbal product derived from the plant Cannabis sativa, as well as pharmaceutical preparations. The legalization of medicinal cannabis (marijuana) in many jurisdictions and widespread public advocacy has propelled an interest in use either by prescription or self-medication. In this review, we examine current evidence for efficacy and adverse effects of any cannabinoid product in rheumatic conditions. The evidence to date is scant and precludes making recommendations for the use of cannabinoid preparations in rheumatology patients. In particular, the risks of herbal cannabis in patients are not well defined. Anecdote and advocacy cannot supersede sound evidence.

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References
1.
Fitzcharles M, Ste-Marie P, Clauw D, Jamal S, Karsh J, LeClercq S . Rheumatologists lack confidence in their knowledge of cannabinoids pertaining to the management of rheumatic complaints. BMC Musculoskelet Disord. 2014; 15:258. PMC: 4121007. DOI: 10.1186/1471-2474-15-258. View

2.
Huestis M . Human cannabinoid pharmacokinetics. Chem Biodivers. 2007; 4(8):1770-804. PMC: 2689518. DOI: 10.1002/cbdv.200790152. View

3.
Stein C, Schafer M, Machelska H . Attacking pain at its source: new perspectives on opioids. Nat Med. 2003; 9(8):1003-8. DOI: 10.1038/nm908. View

4.
Cooper Z, Haney M . Comparison of subjective, pharmacokinetic, and physiological effects of marijuana smoked as joints and blunts. Drug Alcohol Depend. 2009; 103(3):107-13. PMC: 2776770. DOI: 10.1016/j.drugalcdep.2009.01.023. View

5.
Jouanjus E, Lapeyre-Mestre M, Micallef J . Cannabis use: signal of increasing risk of serious cardiovascular disorders. J Am Heart Assoc. 2014; 3(2):e000638. PMC: 4187498. DOI: 10.1161/JAHA.113.000638. View