Therapeutic Potential of Stem Cells Strategy for Cardiovascular Diseases

Overview

Journal Stem Cells Int

Publisher Wiley

Specialty Cell Biology

Date 2016 Nov 11

PMID 27829839

Citations 14

Authors

Chang Youn Lee

Ran Kim

Onju Ham

Jihyun Lee

Pilseog Kim

Seokyeon Lee

Sekyung Oh

Hojin Lee

MinYoung Lee

Jongmin Kim

Woochul Chang

Affiliations

Soon will be listed here.

Abstract

Despite development of medicine, cardiovascular diseases (CVDs) are still the leading cause of mortality and morbidity worldwide. Over the past 10 years, various stem cells have been utilized in therapeutic strategies for the treatment of CVDs. CVDs are characterized by a broad range of pathological reactions including inflammation, necrosis, hyperplasia, and hypertrophy. However, the causes of CVDs are still unclear. While there is a limit to the currently available target-dependent treatments, the therapeutic potential of stem cells is very attractive for the treatment of CVDs because of their paracrine effects, anti-inflammatory activity, and immunomodulatory capacity. Various studies have recently reported increased therapeutic potential of transplantation of microRNA- (miRNA-) overexpressing stem cells or small-molecule-treated cells. In addition to treatment with drugs or overexpressed miRNA in stem cells, stem cell-derived extracellular vesicles also have therapeutic potential because they can deliver the stem cell-specific RNA and protein into the host cell, thereby improving cell viability. Here, we reported the state of stem cell-based therapy for the treatment of CVDs and the potential for cell-free based therapy.

Citing Articles

Epicardial transplantation of antioxidant polyurethane scaffold based human amniotic epithelial stem cell patch for myocardial infarction treatment.

Li J, Yao Y, Zhou J, Yang Z, Qiu C, Lu Y Nat Commun. 2024; 15(1):9105.

PMID: 39438477 PMC: 11496666. DOI: 10.1038/s41467-024-53531-8.

Progress in Biomaterials for Cardiac Tissue Engineering and Regeneration.

Udriste A, Niculescu A, Iliuta L, Bajeu T, Georgescu A, Grumezescu A Polymers (Basel). 2023; 15(5).

PMID: 36904419 PMC: 10007484. DOI: 10.3390/polym15051177.

Extracellular Vesicles from NMN Preconditioned Mesenchymal Stem Cells Ameliorated Myocardial Infarction via miR-210-3p Promoted Angiogenesis.

Pu Y, Li C, Qi X, Xu R, Dong L, Jiang Y Stem Cell Rev Rep. 2023; 19(4):1051-1066.

PMID: 36696015 PMC: 10185590. DOI: 10.1007/s12015-022-10499-6.

Cardiac stem cells: Current knowledge and future prospects.

Mehanna R, Essawy M, Barkat M, Awaad A, Thabet E, Hamed H World J Stem Cells. 2022; 14(1):1-40.

PMID: 35126826 PMC: 8788183. DOI: 10.4252/wjsc.v14.i1.1.

Hyaluronate supports hESC-cardiomyocyte cell therapy for cardiac regeneration after acute myocardial infarction.

Tan Y, Wang L, Chen G, Liu W, Li Z, Wang Y Cell Prolif. 2020; 53(12):e12942.

PMID: 33107673 PMC: 7705924. DOI: 10.1111/cpr.12942.

References

Perea-Gil I, Monguio-Tortajada M, Galvez-Monton C, Bayes-Genis A, Borras F, Roura S . Preclinical evaluation of the immunomodulatory properties of cardiac adipose tissue progenitor cells using umbilical cord blood mesenchymal stem cells: a direct comparative study. Biomed Res Int. 2015; 2015:439808. PMC: 4377370. DOI: 10.1155/2015/439808. View

Zhao T, Zhang Z, Rong Z, Xu Y . Immunogenicity of induced pluripotent stem cells. Nature. 2011; 474(7350):212-5. DOI: 10.1038/nature10135. View

Yde P, Mengel B, Jensen M, Krishna S, Trusina A . Modeling the NF-κB mediated inflammatory response predicts cytokine waves in tissue. BMC Syst Biol. 2011; 5:115. PMC: 3152534. DOI: 10.1186/1752-0509-5-115. View

Chang W, Lee C, Park J, Park M, Maeng L, Yoon C . Survival of hypoxic human mesenchymal stem cells is enhanced by a positive feedback loop involving miR-210 and hypoxia-inducible factor 1. J Vet Sci. 2013; 14(1):69-76. PMC: 3615234. DOI: 10.4142/jvs.2013.14.1.69. View

Lai R, Arslan F, Lee M, Sze N, Choo A, Chen T . Exosome secreted by MSC reduces myocardial ischemia/reperfusion injury. Stem Cell Res. 2010; 4(3):214-22. DOI: 10.1016/j.scr.2009.12.003. View

Takahashi Y, Nishikawa M, Shinotsuka H, Matsui Y, Ohara S, Imai T . Visualization and in vivo tracking of the exosomes of murine melanoma B16-BL6 cells in mice after intravenous injection. J Biotechnol. 2013; 165(2):77-84. DOI: 10.1016/j.jbiotec.2013.03.013. View

Poulsom R, Alison M, Forbes S, Wright N . Adult stem cell plasticity. J Pathol. 2002; 197(4):441-56. DOI: 10.1002/path.1176. View

Ohnishi S, Sumiyoshi H, Kitamura S, Nagaya N . Mesenchymal stem cells attenuate cardiac fibroblast proliferation and collagen synthesis through paracrine actions. FEBS Lett. 2007; 581(21):3961-6. DOI: 10.1016/j.febslet.2007.07.028. View

Gnecchi M, Zhang Z, Ni A, Dzau V . Paracrine mechanisms in adult stem cell signaling and therapy. Circ Res. 2008; 103(11):1204-19. PMC: 2667788. DOI: 10.1161/CIRCRESAHA.108.176826. View

10.

Rahimi A, Spertus J, Reid K, Bernheim S, Krumholz H . Financial barriers to health care and outcomes after acute myocardial infarction. JAMA. 2007; 297(10):1063-72. DOI: 10.1001/jama.297.10.1063. View

11.

Ivey K, Muth A, Arnold J, King F, Yeh R, Fish J . MicroRNA regulation of cell lineages in mouse and human embryonic stem cells. Cell Stem Cell. 2008; 2(3):219-29. PMC: 2293325. DOI: 10.1016/j.stem.2008.01.016. View

12.

Liu M, Li X, Sun R, Zeng Y, Chen S, Zhang P . Vitamin D nutritional status and the risk for cardiovascular disease. Exp Ther Med. 2016; 11(4):1189-1193. PMC: 4812533. DOI: 10.3892/etm.2016.3047. View

13.

Elliott P, Andersson B, Arbustini E, Bilinska Z, Cecchi F, Charron P . Classification of the cardiomyopathies: a position statement from the European Society Of Cardiology Working Group on Myocardial and Pericardial Diseases. Eur Heart J. 2007; 29(2):270-6. DOI: 10.1093/eurheartj/ehm342. View

14.

De Ugarte D, Alfonso Z, ZuK P, Elbarbary A, Zhu M, Ashjian P . Differential expression of stem cell mobilization-associated molecules on multi-lineage cells from adipose tissue and bone marrow. Immunol Lett. 2003; 89(2-3):267-70. DOI: 10.1016/s0165-2478(03)00108-1. View

15.

Vrijsen K, Sluijter J, Schuchardt M, van Balkom B, Noort W, Chamuleau S . Cardiomyocyte progenitor cell-derived exosomes stimulate migration of endothelial cells. J Cell Mol Med. 2010; 14(5):1064-70. PMC: 3822742. DOI: 10.1111/j.1582-4934.2010.01081.x. View

16.

Lai R, Chen T, Lim S . Mesenchymal stem cell exosome: a novel stem cell-based therapy for cardiovascular disease. Regen Med. 2011; 6(4):481-92. DOI: 10.2217/rme.11.35. View

17.

Lu X, Zhao T . Clinical therapy using iPSCs: hopes and challenges. Genomics Proteomics Bioinformatics. 2013; 11(5):294-8. PMC: 4357821. DOI: 10.1016/j.gpb.2013.09.002. View

18.

Eaker E, Sullivan L, Kelly-Hayes M, DAgostino Sr R, Benjamin E . Marital status, marital strain, and risk of coronary heart disease or total mortality: the Framingham Offspring Study. Psychosom Med. 2007; 69(6):509-13. DOI: 10.1097/PSY.0b013e3180f62357. View

19.

Okita K, Ichisaka T, Yamanaka S . Generation of germline-competent induced pluripotent stem cells. Nature. 2007; 448(7151):313-7. DOI: 10.1038/nature05934. View

20.

Smoller J, Pollack M, Wassertheil-Smoller S, Jackson R, Oberman A, Wong N . Panic attacks and risk of incident cardiovascular events among postmenopausal women in the Women's Health Initiative Observational Study. Arch Gen Psychiatry. 2007; 64(10):1153-60. DOI: 10.1001/archpsyc.64.10.1153. View