Short-term Exposures to Ambient Air Pollution and Risk of Recurrent Ischemic Stroke

Overview

Journal Environ Res

Publisher Elsevier

Specialty Environmental Health

Date 2016 Nov 10

PMID 27829205

Citations 7

Authors

Jeffrey J Wing

Sara D Adar

Brisa N Sanchez

Lewis B Morgenstern

Melinda A Smith

Lynda D Lisabeth

Affiliations

Soon will be listed here.

Abstract

Objective: To investigate the association between short-term changes in ambient pollution (particulate matter <2.5µm in aerodynamic diameter (PM) and ozone (O)) and the risk of recurrent ischemic stroke among individuals living in a bi-ethnic community.

Methods: We identified recurrent ischemic stroke cases from the population-based Brain Attack Surveillance in Corpus Christi (BASIC) project between 2000 and 2012. Associations between PM (mean 24-h) and O (maximal 8-h) levels, measured on the previous day, and odds of ischemic stroke were assessed using a time-stratified case-crossover design and modeled using conditional logistic regression.

Results: There were 317 recurrent ischemic strokes after excluding 41 strokes that occurred on days with missing air pollution data. Mean age was 72 years (SD=12) and median time to stroke recurrence was 1.1 years (IQR: 0.2-2.8 years). Median levels of PM and O over the study period were 7.7μg/m (IQR: 5.6-10.7μg/m) and 35.2 ppb (IQR: 25.0-46.1 ppb), respectively. We observed no associations between previous-day PM and O and odds of recurrent stroke (OR=0.95 per 10µg/m of PM, 95% CI: 0.71-1.28 and OR=0.97 per 10ppb of O, 95% CI: 0.87-1.07) after adjusting for ambient temperature and relative humidity. Co-adjustment of both pollutants did not change the results.

Conclusion: We found no evidence of associations between previous-day air pollution levels and recurrent ischemic stroke. Research on the influence of air pollutants on risk of stroke recurrence is still in its infancy, and more research is necessary in studies that are adequately powered to understand the relation.

Citing Articles

Air pollution and stroke hospitalization in the Beibu Gulf Region of China: A case-crossover analysis.

Li M, Edgell R, Wei J, Li H, Qian Z, Feng J Ecotoxicol Environ Saf. 2023; 255:114814.

PMID: 36965278 PMC: 10107400. DOI: 10.1016/j.ecoenv.2023.114814.

Air Pollution and Ischaemic Stroke.

Ho J, Jou E, Tan B, Sharma V Ann Indian Acad Neurol. 2022; 25(Suppl 1):S26-S34.

PMID: 36213103 PMC: 9540827. DOI: 10.4103/aian.aian_1130_21.

Association between exposure to ambient air pollution and hospital admission, incidence, and mortality of stroke: an updated systematic review and meta-analysis of more than 23 million participants.

Niu Z, Liu F, Yu H, Wu S, Xiang H Environ Health Prev Med. 2021; 26(1):15.

PMID: 33499804 PMC: 7839211. DOI: 10.1186/s12199-021-00937-1.

Identifying and assessing the impact of key neighborhood-level determinants on geographic variation in stroke: a machine learning and multilevel modeling approach.

Ji J, Hu L, Liu B, Li Y BMC Public Health. 2020; 20(1):1666.

PMID: 33160324 PMC: 7648288. DOI: 10.1186/s12889-020-09766-3.

Short-term associations between ambient air pollution and stroke hospitalisations: time-series study in Shenzhen, China.

Guo Y, Xie X, Lei L, Zhou H, Deng S, Xu Y BMJ Open. 2020; 10(3):e032974.

PMID: 32198300 PMC: 7103818. DOI: 10.1136/bmjopen-2019-032974.

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