Mechanistic Insights into Mammalian Stress Granule Dynamics

Overview

Journal J Cell Biol

Specialty Cell Biology

Date 2016 Nov 9

PMID 27821493

Citations 196

Authors

Marc D Panas

Pavel Ivanov

Paul Anderson

Affiliations

Soon will be listed here.

Abstract

The accumulation of stalled translation preinitiation complexes (PICs) mediates the condensation of stress granules (SGs). Interactions between prion-related domains and intrinsically disordered protein regions found in SG-nucleating proteins promote the condensation of ribonucleoproteins into SGs. We propose that PIC components, especially 40S ribosomes and mRNA, recruit nucleators that trigger SG condensation. With resolution of stress, translation reinitiation reverses this process and SGs disassemble. By cooperatively modulating the assembly and disassembly of SGs, ribonucleoprotein condensation can influence the survival and recovery of cells exposed to unfavorable environmental conditions.

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