Associations of Proteins Relevant to MAPK Signaling Pathway (p38MAPK-1,HIF-1 and HO-1) with Coronary Lesion Characteristics and Prognosis of Peri-menopausal Women

Overview

Journal Lipids Health Dis

Publisher Biomed Central

Specialties Biochemistry
Endocrinology

Date 2016 Nov 9

PMID 27821168

Citations 4

Authors

Liqiu Yan

Xufen Cao

Saitian Zeng

Zhe Li

Zheng Lian

Jiawang Wang

Fengfeng Lv

Yunfei Wang

Yanshen Li

Affiliations

Soon will be listed here.

Abstract

Background: The present study was intended to explore whether three proteins within MAPK signaling pathway (i.e. p38MAPK-1, HIF-1 and HO-1) were correlated with peri-menopausal women's coronary lesion features and prognosis.

Methods: Altogether 1449 peri-menopausal women were divided into non-coronary artery disease (CAD) group (n = 860) and CAD group (n = 589), including 167 pre-menopausal CAD populations and 422 post-menopausal CAD populations. General information about CAD risk parameters were gathered, including age, family history of CAD or hypertension or diabetes mellitus, bilirubin, cholesterol, triglyceride, high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) and so on. Coronary angiography results were judged, and CAD score was calculated with application of Genisin scoring method. Besides, detection of MAPK-1 levels was implemented with Strept Avidin-Biotin Complex (SABC) method, while HIF-1 and HO-1 expressions in the serum were determined utilizing ELISA detection kit. Correlations among protein expressions, characteristics of coronary lesions and prognosis of CAD populations were finally evaluated.

Results: Hypertension, hyperlipoidemia, diabetes and smoking history were more prevalent among postmenopausal CAD women than premenopausal CAD women (P < 0.05). Furthermore, postmenopausal women seemed to be significantly associated with multiple (i.e. double and triple) vessel lesions and severe lesion types (type B and C), when compared with premenopausal CAD group (P < 0.05). Similarly, remarkably elevated expressions of p38MAPK-1, HIF-1 and HO-1 were found within postmenopausal CAD populations in comparison to premenopausal ones (P < 0.05). The internal CysC, hs-CRP, TG and LDL-C concentrations all accorded with the following tendency: postmenopausal CAD women > premenopausal CAD women > non-CAD women. Moreover, p38MAPK-1, HIF-1 and HO-1 expressions were up-regulated with increasing number of vessel lesions and severity of coronary lesions among peri-menopausal women. Besides, among both pre-menopausal and post-menopausal CAD groups, positive correlations could be observed between MAPK-1 and TG (r = 0.271; r = 0.476), between HIF-1α and LDL-C (r = 0.077; r = 0.470), as well as between HO-1 and CysC (r = 0.492; r = 0.190) or hs-CRP (r = 0.569; r = 0.542) (all P < 0.05). MAPK-1, HIF-1α and HO-1 were also, respectively, positively correlated with CysC (r = 0.415), hs-CRP (r = 0.137), and TG (r = 0.142), regarding post-menopausal CAD women (all P < 0.05). Finally, only SBP and TG were regarded as independent risk factors for CAD prognosis (i.e. high Genisin score) among premenopausal women (OR = 1.02, 95%CI: 1.01-1.18, P = 0.043; OR = 1.82, 95%CI: 1.01-3.33, P = 0.047).

Conclusions: Expressions of p38MAPK-1, HIF-1 and HO-1 could serve as predictive roles for coronary lesions among peri-menopausal women.

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References

Devaraj S, Xu D, Jialal I . C-reactive protein increases plasminogen activator inhibitor-1 expression and activity in human aortic endothelial cells: implications for the metabolic syndrome and atherothrombosis. Circulation. 2003; 107(3):398-404. DOI: 10.1161/01.cir.0000052617.91920.fd. View

Regitz-Zagrosek V . Cardiovascular disease in postmenopausal women. Climacteric. 2004; 6 Suppl 3:13-20. View

Nijm J, Jonasson L . Inflammation and cortisol response in coronary artery disease. Ann Med. 2008; 41(3):224-33. DOI: 10.1080/07853890802508934. View

Peyton K, Reyna S, Chapman G, Ensenat D, Liu X, Wang H . Heme oxygenase-1-derived carbon monoxide is an autocrine inhibitor of vascular smooth muscle cell growth. Blood. 2002; 99(12):4443-8. DOI: 10.1182/blood.v99.12.4443. View

Kido M, Du L, Sullivan C, Li X, Deutsch R, Jamieson S . Hypoxia-inducible factor 1-alpha reduces infarction and attenuates progression of cardiac dysfunction after myocardial infarction in the mouse. J Am Coll Cardiol. 2005; 46(11):2116-24. DOI: 10.1016/j.jacc.2005.08.045. View

Tanaka N, Yonekura H, Yamagishi S, Fujimori H, Yamamoto Y, Yamamoto H . The receptor for advanced glycation end products is induced by the glycation products themselves and tumor necrosis factor-alpha through nuclear factor-kappa B, and by 17beta-estradiol through Sp-1 in human vascular endothelial cells. J Biol Chem. 2000; 275(33):25781-90. DOI: 10.1074/jbc.M001235200. View

Carr M, Brunzell J . Abdominal obesity and dyslipidemia in the metabolic syndrome: importance of type 2 diabetes and familial combined hyperlipidemia in coronary artery disease risk. J Clin Endocrinol Metab. 2004; 89(6):2601-7. DOI: 10.1210/jc.2004-0432. View

Yan H, Ma X, Chen X, Li Y, Shao L, Dixon C . Delayed increase of tyrosine hydroxylase expression in rat nigrostriatal system after traumatic brain injury. Brain Res. 2007; 1134(1):171-9. PMC: 4017583. DOI: 10.1016/j.brainres.2006.11.087. View

Cai Z, Zhong H, Bosch-Marce M, Fox-Talbot K, Wang L, Wei C . Complete loss of ischaemic preconditioning-induced cardioprotection in mice with partial deficiency of HIF-1 alpha. Cardiovasc Res. 2007; 77(3):463-70. DOI: 10.1093/cvr/cvm035. View

10.

Holweg C, Balk A, Snaathorst J, van den Engel S, Niesters H, Maat A . Intragraft heme oxygenase-1 and coronary artery disease after heart transplantation. Transpl Immunol. 2004; 13(4):265-72. DOI: 10.1016/j.trim.2004.08.002. View

11.

Graham I, Atar D, Borch-Johnsen K, Boysen G, Burell G, Cifkova R . European guidelines on cardiovascular disease prevention in clinical practice: executive summary. Fourth Joint Task Force of the European Society of Cardiology and other societies on cardiovascular disease prevention in clinical practice.... Eur J Cardiovasc Prev Rehabil. 2007; 14 Suppl 2:E1-40. DOI: 10.1097/01.hjr.0000277984.31558.c4. View

12.

Ford E, Capewell S . Coronary heart disease mortality among young adults in the U.S. from 1980 through 2002: concealed leveling of mortality rates. J Am Coll Cardiol. 2007; 50(22):2128-32. DOI: 10.1016/j.jacc.2007.05.056. View

13.

Caretti A, Morel S, Milano G, Fantacci M, Bianciardi P, Ronchi R . Heart HIF-1alpha and MAP kinases during hypoxia: are they associated in vivo?. Exp Biol Med (Maywood). 2007; 232(7):887-94. View

14.

Lambadiari V, Kadoglou N, Stasinos V, Maratou E, Antoniadis A, Kolokathis F . Serum levels of retinol-binding protein-4 are associated with the presence and severity of coronary artery disease. Cardiovasc Diabetol. 2014; 13:121. PMC: 4156962. DOI: 10.1186/s12933-014-0121-z. View

15.

Khandrika L, Lieberman R, Koul S, Kumar B, Maroni P, Chandhoke R . Hypoxia-associated p38 mitogen-activated protein kinase-mediated androgen receptor activation and increased HIF-1alpha levels contribute to emergence of an aggressive phenotype in prostate cancer. Oncogene. 2009; 28(9):1248-60. PMC: 2651999. DOI: 10.1038/onc.2008.476. View

16.

De S, Searles G, Haddad H . The prevalence of cardiac risk factors in women 45 years of age or younger undergoing angiography for evaluation of undiagnosed chest pain. Can J Cardiol. 2002; 18(9):945-8. View

17.

Djousse L, Levy D, Cupples L, Evans J, DAgostino R, Ellison R . Total serum bilirubin and risk of cardiovascular disease in the Framingham offspring study. Am J Cardiol. 2001; 87(10):1196-200; A4, 7. DOI: 10.1016/s0002-9149(01)01494-1. View

18.

Wang M, Tsai B, Reiger K, Brown J, Meldrum D . 17-beta-Estradiol decreases p38 MAPK-mediated myocardial inflammation and dysfunction following acute ischemia. J Mol Cell Cardiol. 2006; 40(2):205-12. DOI: 10.1016/j.yjmcc.2005.06.019. View

19.

Otterbein L, Choi A . Heme oxygenase: colors of defense against cellular stress. Am J Physiol Lung Cell Mol Physiol. 2000; 279(6):L1029-37. DOI: 10.1152/ajplung.2000.279.6.L1029. View

20.

Weidemann A, Johnson R . Biology of HIF-1alpha. Cell Death Differ. 2008; 15(4):621-7. DOI: 10.1038/cdd.2008.12. View