I-Wire Heart-on-a-Chip I: Three-dimensional Cardiac Tissue Constructs for Physiology and Pharmacology

Overview

Journal Acta Biomater

Publisher Elsevier

Specialty Biomedical Engineering

Date 2016 Nov 8

PMID 27818308

Citations 53

Authors

Veniamin Y Sidorov

Philip C Samson

Tatiana N Sidorova

Jeffrey M Davidson

Chee C Lim

John P Wikswo

Affiliations

Soon will be listed here.

Abstract

Statement Of Significance: There is a growing interest in creating engineered heart tissue constructs for basic cardiac research, applied research in cardiac pharmacology, and repair of damaged hearts. We address an unmet need to characterize fully the performance of these tissues with our simple "I-Wire" assay that allows application of controlled forces to three-dimensional cardiac fiber constructs and measurement of both the electrical and mechanical properties of the construct. The advantage of I-Wire over other approaches is that the constructs being measured are truly three-dimensional, rather than a single layer of cells grown within a microfluidic device. We anticipate that the I-Wire will be extremely useful for the evaluation of myocardial constructs created using cardiomyocytes derived from human induced pluripotent stem cells.

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