Immune Regulation in Pregnancy: A Matter of Perspective?

Overview

Journal Obstet Gynecol Clin North Am

Specialty Gynecology & Obstetrics

Date 2016 Nov 7

PMID 27816154

Citations 41

Authors

Elizabeth A Bonney

Affiliations

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Abstract

The maternal immune system is complex and governed by multiple hormonal and metabolic factors, including those provided to the mother via the fetus. Understanding of the balance between maternal tolerance and protection of the fetus may require thinking from multiple theoretical approaches to the general problem of immune activation and tolerance. This article provides a brief review of the immune system, with aspects relevant to pregnancy. The references include reviews that expand on the elements discussed. The article also uses different models of immune system activation and tolerance to provide a theoretical understanding of the problem of maternal tolerance.

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References

Adams E, Gu S, Luoma A . Human gamma delta T cells: Evolution and ligand recognition. Cell Immunol. 2015; 296(1):31-40. PMC: 4466157. DOI: 10.1016/j.cellimm.2015.04.008. View

Constantin C, Masopust D, Gourley T, Grayson J, Strickland O, Ahmed R . Normal establishment of virus-specific memory CD8 T cell pool following primary infection during pregnancy. J Immunol. 2007; 179(7):4383-9. DOI: 10.4049/jimmunol.179.7.4383. View

Yellon S, Dobyns A, Beck H, Kurtzman J, Garfield R, Kirby M . Loss of progesterone receptor-mediated actions induce preterm cellular and structural remodeling of the cervix and premature birth. PLoS One. 2013; 8(12):e81340. PMC: 3858221. DOI: 10.1371/journal.pone.0081340. View

Lawson V . Turned on by danger: activation of CD1d-restricted invariant natural killer T cells. Immunology. 2012; 137(1):20-7. PMC: 3449243. DOI: 10.1111/j.1365-2567.2012.03612.x. View

Gattinoni L, Finkelstein S, Klebanoff C, Antony P, Palmer D, Spiess P . Removal of homeostatic cytokine sinks by lymphodepletion enhances the efficacy of adoptively transferred tumor-specific CD8+ T cells. J Exp Med. 2005; 202(7):907-12. PMC: 1397916. DOI: 10.1084/jem.20050732. View

Menzies F, Higgins C, Shepherd M, Nibbs R, Nelson S . Mast cells reside in myometrium and cervix, but are dispensable in mice for successful pregnancy and labor. Immunol Cell Biol. 2011; 90(3):321-9. DOI: 10.1038/icb.2011.40. View

Kwan M, Hazan A, Zhang J, Jones R, Harris L, Whittle W . Dynamic changes in maternal decidual leukocyte populations from first to second trimester gestation. Placenta. 2014; 35(12):1027-34. DOI: 10.1016/j.placenta.2014.09.018. View

Caluwaerts S, Fautsch T, Lagrou D, Moreau M, Camara A, Gunther S . Dilemmas in Managing Pregnant Women With Ebola: 2 Case Reports. Clin Infect Dis. 2015; 62(7):903-905. PMC: 4787604. DOI: 10.1093/cid/civ1024. View

Bytautiene E, Vedernikov Y, Maner W, Saade G, Romero R, Garfield R . Challenge with ovalbumin antigen increases uterine and cervical contractile activity in sensitized guinea pigs. Am J Obstet Gynecol. 2008; 199(6):658.e1-6. DOI: 10.1016/j.ajog.2008.06.036. View

10.

Cao B, Mysorekar I . Intracellular bacteria in placental basal plate localize to extravillous trophoblasts. Placenta. 2014; 35(2):139-42. DOI: 10.1016/j.placenta.2013.12.007. View

11.

Muzzio D, Soldati R, Ehrhardt J, Utpatel K, Evert M, Zenclussen A . B cell development undergoes profound modifications and adaptations during pregnancy in mice. Biol Reprod. 2014; 91(5):115. DOI: 10.1095/biolreprod.114.122366. View

12.

Anderson C, Matzinger P . Danger: the view from the bottom of the cliff. Semin Immunol. 2000; 12(3):231-8; discussion 257-344. DOI: 10.1006/smim.2000.0236. View

13.

Gupta P, Godec J, Wolski D, Adland E, Yates K, Pauken K . CD39 Expression Identifies Terminally Exhausted CD8+ T Cells. PLoS Pathog. 2015; 11(10):e1005177. PMC: 4618999. DOI: 10.1371/journal.ppat.1005177. View

14.

Bruckmann A, Seeliger C, Lehmann T, Schleussner E, Schlembach D . Altered retinal flicker response indicates microvascular dysfunction in women with preeclampsia. Hypertension. 2015; 66(4):900-5. DOI: 10.1161/HYPERTENSIONAHA.115.05734. View

15.

Menon M, Blair P, Isenberg D, Mauri C . A Regulatory Feedback between Plasmacytoid Dendritic Cells and Regulatory B Cells Is Aberrant in Systemic Lupus Erythematosus. Immunity. 2016; 44(3):683-697. PMC: 4803914. DOI: 10.1016/j.immuni.2016.02.012. View

16.

Medzhitov R . Approaching the asymptote: 20 years later. Immunity. 2009; 30(6):766-75. DOI: 10.1016/j.immuni.2009.06.004. View

17.

Timmons B, Fairhurst A, Mahendroo M . Temporal changes in myeloid cells in the cervix during pregnancy and parturition. J Immunol. 2009; 182(5):2700-7. PMC: 2752643. DOI: 10.4049/jimmunol.0803138. View

18.

Uemura Y, Suzuki M, Liu T, Narita Y, Hirata S, Ohyama H . Role of human non-invariant NKT lymphocytes in the maintenance of type 2 T helper environment during pregnancy. Int Immunol. 2008; 20(3):405-12. DOI: 10.1093/intimm/dxn001. View

19.

Gopal R, Rangel-Moreno J, Junecko B, Mallon D, Chen K, Pociask D . Mucosal pre-exposure to Th17-inducing adjuvants exacerbates pathology after influenza infection. Am J Pathol. 2013; 184(1):55-63. PMC: 3873493. DOI: 10.1016/j.ajpath.2013.09.012. View

20.

Lazarus J, Parkes A, Premawardhana L . Postpartum thyroiditis. Autoimmunity. 2002; 35(3):169-73. DOI: 10.1080/08916930290031667. View