Human Mesenchymal Stem Cells (MSCs) for Treatment Towards Immune- and Inflammation-mediated Diseases: Review of Current Clinical Trials

Overview

Journal J Biomed Sci

Publisher Biomed Central

Specialty Biology

Date 2016 Nov 5

PMID 27809910

Citations 164

Authors

Li-Tzu Wang

Chiao-Hsuan Ting

Men-Luh Yen

Ko-Jiunn Liu

Huey-Kang Sytwu

Kenneth K Wu

B Linju Yen

Affiliations

Soon will be listed here.

Abstract

Human mesenchymal stem cells (MSCs) are multilineage somatic progenitor/stem cells that have been shown to possess immunomodulatory properties in recent years. Initially met with much skepticism, MSC immunomodulation has now been well reproduced across tissue sources and species to be clinically relevant. This has opened up the use of these versatile cells for application as 3rd party/allogeneic use in cell replacement/tissue regeneration, as well as for immune- and inflammation-mediated disease entities. Most surprisingly, use of MSCs for in immune-/inflammation-mediated diseases appears to yield more efficacy than for regenerative medicine, since engraftment of the exogenous cell does not appear necessary. In this review, we focus on this non-traditional clinical use of a tissue-specific stem cell, and highlight important findings and trends in this exciting area of stem cell therapy.

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