Observation of Implied Motion in a Work of Art Modulates Cortical Connectivity and Plasticity

Overview

Journal J Exerc Rehabil

Date 2016 Nov 4

PMID 27807519

Citations 4

Authors

Carmen Concerto

Carmenrita Infortuna

Ludovico Mineo

Manuel Pereira

David Freedberg

Eileen Chusid

Eugenio Aguglia

Fortunato Battaglia

Affiliations

Soon will be listed here.

Abstract

Following the discovery of mirror neurons, much attention has been de-voted to understanding the neural responses evoked by observation of implied motion in works of art. Neuroimaging studies have demonstrated that dorsal premotor cortex (PMd) is commonly involved during observation of movements but the role of the inhibitory and excitatory connections between PMd and primary motor cortex (M1) during observation of implied motion remains uncertain. In this study, using high and low frequency repetitive transcranial magnetic stimulation (rTMS), we examined PMd-M1 connectivity and plasticity during observation of Michelangelo's frescos with and without implied motion (Sistine Chapel, 1508-1512). We found that observation of implied motion in a painting specifically reduces the activity of inhibitory PMd-M1 connections. On the contrary PMd-M1 facilitatory connections, as examined by means of 5-Hz rTMS, were not modulated during observation of the painting. Our data suggest that observation of implied motion in a painting modulates PMd-M1 connectivity and plasticity. These results are consistent with the hypothesis that art with implied motion might be used as a plasticity-based intervention in rehabilitation.

Citing Articles

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References

Gerschlager W, Siebner H, Rothwell J . Decreased corticospinal excitability after subthreshold 1 Hz rTMS over lateral premotor cortex. Neurology. 2001; 57(3):449-55. DOI: 10.1212/wnl.57.3.449. View

Baumer T, Lange R, Liepert J, Weiller C, Siebner H, Rothwell J . Repeated premotor rTMS leads to cumulative plastic changes of motor cortex excitability in humans. Neuroimage. 2003; 20(1):550-60. DOI: 10.1016/s1053-8119(03)00310-0. View

David , Senior . Implicit motion and the brain. Trends Cogn Sci. 2000; 4(8):293-295. DOI: 10.1016/s1364-6613(00)01511-4. View

Rizzo V, Siebner H, Modugno N, Pesenti A, Munchau A, Gerschlager W . Shaping the excitability of human motor cortex with premotor rTMS. J Physiol. 2003; 554(Pt 2):483-95. PMC: 1664763. DOI: 10.1113/jphysiol.2003.048777. View

Dimyan M, Cohen L . Neuroplasticity in the context of motor rehabilitation after stroke. Nat Rev Neurol. 2011; 7(2):76-85. PMC: 4886719. DOI: 10.1038/nrneurol.2010.200. View

Mulder T . Motor imagery and action observation: cognitive tools for rehabilitation. J Neural Transm (Vienna). 2007; 114(10):1265-78. PMC: 2797860. DOI: 10.1007/s00702-007-0763-z. View

Cisek P, Kalaska J . Neural correlates of mental rehearsal in dorsal premotor cortex. Nature. 2004; 431(7011):993-6. DOI: 10.1038/nature03005. View

Rizzolatti G, Fadiga L . Grasping objects and grasping action meanings: the dual role of monkey rostroventral premotor cortex (area F5). Novartis Found Symp. 1999; 218:81-95; discussion 95-103. DOI: 10.1002/9780470515563.ch6. View

Szameitat A, Shen S, Sterr A . Motor imagery of complex everyday movements. An fMRI study. Neuroimage. 2006; 34(2):702-13. DOI: 10.1016/j.neuroimage.2006.09.033. View

10.

Chen R, Samii A, Canos M, Wassermann E, Hallett M . Effects of phenytoin on cortical excitability in humans. Neurology. 1997; 49(3):881-3. DOI: 10.1212/wnl.49.3.881. View

11.

Fridman E, Hanakawa T, Chung M, Hummel F, Leiguarda R, Cohen L . Reorganization of the human ipsilesional premotor cortex after stroke. Brain. 2004; 127(Pt 4):747-58. DOI: 10.1093/brain/awh082. View

12.

Johansen-Berg H, Rushworth M, Bogdanovic M, Kischka U, Wimalaratna S, Matthews P . The role of ipsilateral premotor cortex in hand movement after stroke. Proc Natl Acad Sci U S A. 2002; 99(22):14518-23. PMC: 137915. DOI: 10.1073/pnas.222536799. View

13.

Munchau A, Bloem B, Irlbacher K, Trimble M, Rothwell J . Functional connectivity of human premotor and motor cortex explored with repetitive transcranial magnetic stimulation. J Neurosci. 2002; 22(2):554-61. PMC: 6758651. View

14.

Miller B, Hou C . Portraits of artists: emergence of visual creativity in dementia. Arch Neurol. 2004; 61(6):842-4. DOI: 10.1001/archneur.61.6.842. View

15.

Passingham R . Premotor cortex: sensory cues and movement. Behav Brain Res. 1985; 18(2):175-85. DOI: 10.1016/0166-4328(85)90073-7. View

16.

Urgesi C, Moro V, Candidi M, Aglioti S . Mapping implied body actions in the human motor system. J Neurosci. 2006; 26(30):7942-9. PMC: 6674209. DOI: 10.1523/JNEUROSCI.1289-06.2006. View

17.

Cela-Conde C, Marty G, Maestu F, Ortiz T, Munar E, Fernandez A . Activation of the prefrontal cortex in the human visual aesthetic perception. Proc Natl Acad Sci U S A. 2004; 101(16):6321-5. PMC: 395967. DOI: 10.1073/pnas.0401427101. View

18.

Wassermann E . Risk and safety of repetitive transcranial magnetic stimulation: report and suggested guidelines from the International Workshop on the Safety of Repetitive Transcranial Magnetic Stimulation, June 5-7, 1996. Electroencephalogr Clin Neurophysiol. 1998; 108(1):1-16. DOI: 10.1016/s0168-5597(97)00096-8. View

19.

Tkach D, Reimer J, Hatsopoulos N . Congruent activity during action and action observation in motor cortex. J Neurosci. 2007; 27(48):13241-50. PMC: 6673404. DOI: 10.1523/JNEUROSCI.2895-07.2007. View

20.

OShea J, Johansen-Berg H, Trief D, Gobel S, Rushworth M . Functionally specific reorganization in human premotor cortex. Neuron. 2007; 54(3):479-90. DOI: 10.1016/j.neuron.2007.04.021. View