The Pas De Trois of Vitamin D, FGF23, and PTH

Overview

Journal J Am Soc Nephrol

Specialty Nephrology

Date 2016 Nov 4

PMID 27807212

Citations 12

Authors

Tally Naveh-Many

Justin Silver

Affiliations

Soon will be listed here.

Citing Articles

Carotid intima-media thickness, fibroblast growth factor 23, and mineral bone disorder in children with chronic kidney disease.

Palupi-Baroto R, Hermawan K, Murni I, Nurlita T, Prihastuti Y, Puspitawati I BMC Nephrol. 2024; 25(1):369.

PMID: 39433982 PMC: 11494757. DOI: 10.1186/s12882-024-03771-z.

The Intricacies of Renal Phosphate Reabsorption-An Overview.

Walker V Int J Mol Sci. 2024; 25(9).

PMID: 38731904 PMC: 11083860. DOI: 10.3390/ijms25094684.

Potential Role of Novel Cardiovascular Biomarkers in Pediatric Patients with Chronic Kidney Disease.

Abreu M, Vaz de Castro P, Moreira F, de Oliveira Ferreira H, Simoes E Silva A Mini Rev Med Chem. 2023; 24(5):491-506.

PMID: 37231748 DOI: 10.2174/1389557523666230523114331.

Study on the correlation between mineral bone metabolism and CRP in patients with SHPT during perioperative period.

Yan L, Xiong Q, Xu Q, Ren P, Li T, Cao H Immun Inflamm Dis. 2023; 11(4):e828.

PMID: 37102663 PMC: 10091369. DOI: 10.1002/iid3.828.

Molecular Mechanisms of Parathyroid Disorders in Chronic Kidney Disease.

Hassan A, Khalaily N, Kilav-Levin R, Nechama M, Volovelsky O, Silver J Metabolites. 2022; 12(2).

PMID: 35208186 PMC: 8878033. DOI: 10.3390/metabo12020111.

References

Fan Y, Bi R, Densmore M, Sato T, Kobayashi T, Yuan Q . Parathyroid hormone 1 receptor is essential to induce FGF23 production and maintain systemic mineral ion homeostasis. FASEB J. 2015; 30(1):428-40. PMC: 4684518. DOI: 10.1096/fj.15-278184. View

Rhee Y, Bivi N, Farrow E, Lezcano V, Plotkin L, White K . Parathyroid hormone receptor signaling in osteocytes increases the expression of fibroblast growth factor-23 in vitro and in vivo. Bone. 2011; 49(4):636-43. PMC: 3167030. DOI: 10.1016/j.bone.2011.06.025. View

Nguyen-Yamamoto L, Karaplis A, St-Arnaud R, Goltzman D . Fibroblast Growth Factor 23 Regulation by Systemic and Local Osteoblast-Synthesized 1,25-Dihydroxyvitamin D. J Am Soc Nephrol. 2016; 28(2):586-597. PMC: 5280015. DOI: 10.1681/ASN.2016010066. View

Silver J, Naveh-Many T . FGF-23 and secondary hyperparathyroidism in chronic kidney disease. Nat Rev Nephrol. 2013; 9(11):641-9. DOI: 10.1038/nrneph.2013.147. View

Galitzer H, Ben-Dov I, Silver J, Naveh-Many T . Parathyroid cell resistance to fibroblast growth factor 23 in secondary hyperparathyroidism of chronic kidney disease. Kidney Int. 2009; 77(3):211-8. DOI: 10.1038/ki.2009.464. View

Ben-Dov I, Galitzer H, Lavi-Moshayoff V, Goetz R, Kuro-O M, Mohammadi M . The parathyroid is a target organ for FGF23 in rats. J Clin Invest. 2007; 117(12):4003-8. PMC: 2066196. DOI: 10.1172/JCI32409. View

Sato T, Tominaga Y, Ueki T, Goto N, Matsuoka S, Katayama A . Total parathyroidectomy reduces elevated circulating fibroblast growth factor 23 in advanced secondary hyperparathyroidism. Am J Kidney Dis. 2004; 44(3):481-7. View

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Lavi-Moshayoff V, Wasserman G, Meir T, Silver J, Naveh-Many T . PTH increases FGF23 gene expression and mediates the high-FGF23 levels of experimental kidney failure: a bone parathyroid feedback loop. Am J Physiol Renal Physiol. 2010; 299(4):F882-9. DOI: 10.1152/ajprenal.00360.2010. View

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Barthel T, Mathern D, Whitfield G, Haussler C, Hopper 4th H, Hsieh J . 1,25-Dihydroxyvitamin D3/VDR-mediated induction of FGF23 as well as transcriptional control of other bone anabolic and catabolic genes that orchestrate the regulation of phosphate and calcium mineral metabolism. J Steroid Biochem Mol Biol. 2007; 103(3-5):381-8. DOI: 10.1016/j.jsbmb.2006.12.054. View

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Moe S, Chertow G, Parfrey P, Kubo Y, Block G, Correa-Rotter R . Cinacalcet, Fibroblast Growth Factor-23, and Cardiovascular Disease in Hemodialysis: The Evaluation of Cinacalcet HCl Therapy to Lower Cardiovascular Events (EVOLVE) Trial. Circulation. 2015; 132(1):27-39. DOI: 10.1161/CIRCULATIONAHA.114.013876. View

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Kaneko I, Saini R, Griffin K, Whitfield G, Haussler M, Jurutka P . FGF23 gene regulation by 1,25-dihydroxyvitamin D: opposing effects in adipocytes and osteocytes. J Endocrinol. 2015; 226(3):155-66. PMC: 4560246. DOI: 10.1530/JOE-15-0225. View

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Han X, Xiao Z, Quarles L . Membrane and integrative nuclear fibroblastic growth factor receptor (FGFR) regulation of FGF-23. J Biol Chem. 2015; 290(16):10447-59. PMC: 4400353. DOI: 10.1074/jbc.M114.609230. View

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Wohrle S, Bonny O, Beluch N, Gaulis S, Stamm C, Scheibler M . FGF receptors control vitamin D and phosphate homeostasis by mediating renal FGF-23 signaling and regulating FGF-23 expression in bone. J Bone Miner Res. 2011; 26(10):2486-97. DOI: 10.1002/jbmr.478. View

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Meir T, Durlacher K, Pan Z, Amir G, Richards W, Silver J . Parathyroid hormone activates the orphan nuclear receptor Nurr1 to induce FGF23 transcription. Kidney Int. 2014; 86(6):1106-15. DOI: 10.1038/ki.2014.215. View

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Wu A, Feng B, Chen M, Kolumam G, Zavala-Solorio J, Wyatt S . Antibody-mediated activation of FGFR1 induces FGF23 production and hypophosphatemia. PLoS One. 2013; 8(2):e57322. PMC: 3579827. DOI: 10.1371/journal.pone.0057322. View

18.

Hassan A, Durlacher K, Silver J, Naveh-Many T, Levi R . The fibroblast growth factor receptor mediates the increased FGF23 expression in acute and chronic uremia. Am J Physiol Renal Physiol. 2015; 310(3):F217-21. DOI: 10.1152/ajprenal.00332.2015. View